Local Infiltration With Bupivacaine to Increase Quality of Post-operative Pain Control in Total Knee Replacement

Periarticular Injection With Bupivacaine For Post-Operative Pain Control In Total Knee Replacement: A Prospective Randomized Double-Blind Controlled Trial

The purpose of this study is to evaluate the efficacy of periarticular injection with 0.25% bupivacaine for controlling pain after total knee replacement to improve the quality of post-operative care.

Compare post operative pain control after total knee replacement by periarticular injection with 0.25% bupivacaine compare with 0.9% normal saline.

Inclusion Criteria:

• primary osteoarthritis patients undergoing total knee replacement at Siriraj Hospital
• BMI between 20-35
• having a full understanding of the question in this trial

Exclusion Criteria:

• allergy to NSAIDs, Acetaminophen, Bupivacaine
• blood creatinine more than 1.5 mg/dl or creatinine clearance less than 60 mL/min
• abnormal liver function
• previous surgery on the knee undergoing total knee replacement
• patient could not receive spinal anesthesia