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| Name | Class |
|---|---|
| Norwegian University of Science and Technology | OTHER |
| The Royal Norwegian Ministry of Health | OTHER |
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The prevalence of preterm birth is rising in most western countries. The causes of preterm birth is not fully understood and seem to be multifactorial. The endocrine and metabolic aspects are scarcely investigated.The main purpose of this study is to test the hypothesis that endocrine and metabolic factors associate to preterm births.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Preterm birth group | Women with prior preterm birth | ||
| Term birth group | Women with prior term birth |
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| Measure | Description | Time Frame |
|---|---|---|
| The prevalence of PCOS | The prevalence of PCOS will be assessed in both study groups and the difference between the groups will be reported. | one week after enrollment. |
| The prevalence of Diabetes Mellitus | The prevalence of Diabetes Mellitus will be assessed in both study groups and the difference between the groups will be reported. | one week after enrollment |
| Measure | Description | Time Frame |
|---|---|---|
| Ovarian antral follicle count | Difference between study groups. | three years. |
| Difference in quality of life between study groups. | Quality of life will be assessed by using Short form 36 Health Survey Questionnaire (SF- 36) |
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Inclusion Criteria:
Exclusion Criteria:
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All women in municipalities having Namsos Hospital as their local Hospital and with preterm births from January 1999 to Descember 2006 were identifed by searching birth protocols. These women were invited to participate in the preterm birth study group. As controls we identified the first term birth occuring in time after each preterm birth. These women were invited to participate in the term birth study group.
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| Name | Affiliation | Role |
|---|---|---|
| Tina Eilertsen, MD | Namsos Hospital, Nord- Trøndelag Hospital Trust | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Namsos Hospital, Nord- Trøndelag Hospital Trust | Namsos | Nord- Trøndelag | 7800 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22693172 | Derived | Eilertsen TB, Vanky E, Carlsen SM. Anti-Mullerian hormone in the diagnosis of polycystic ovary syndrome: can morphologic description be replaced? Hum Reprod. 2012 Aug;27(8):2494-502. doi: 10.1093/humrep/des213. Epub 2012 Jun 12. | |
| 22168920 | Derived | Eilertsen TB, Vanky E, Carlsen SM. Increased prevalence of diabetes and polycystic ovary syndrome in women with a history of preterm birth: a case-control study. BJOG. 2012 Feb;119(3):266-75. doi: 10.1111/j.1471-0528.2011.03206.x. Epub 2011 Dec 13. |
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| ID | Term |
|---|---|
| D011085 | Polycystic Ovary Syndrome |
| D047928 | Premature Birth |
| D003920 | Diabetes Mellitus |
| D007752 | Obstetric Labor, Premature |
| D017588 | Hyperandrogenism |
| D006628 | Hirsutism |
| D010048 | Ovarian Cysts |
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D003560 | Cysts |
| D009369 | Neoplasms |
| D010049 | Ovarian Diseases |
| D000291 | Adnexal Diseases |
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Whole blood, serum,endometrial biopsy
| four years |
| Serum levels of androgens | Difference between study groups | one year |
| Difference in anxiety between study groups. | Anxiety will be assessed by using Spielberger State Anxiety Inventory Y1 and Y2 (STAI Y1 and Y2). | four years |
| Serum levels of AMH | Difference between study groups | One year |
| Serum levels of glucose | Difference between study groups | One year |
| Serum levels of insulin | Difference between study groups | One year |
| D005831 |
| Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D058489 | 46, XX Disorders of Sex Development |
| D012734 | Disorders of Sex Development |
| D014564 | Urogenital Abnormalities |
| D047808 | Adrenogenital Syndrome |
| D052801 | Male Urogenital Diseases |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D006201 | Hair Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D014770 | Virilism |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |