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| ID | Type | Description | Link |
|---|---|---|---|
| KA04/104 | Other Identifier | Baskent University KA04/104 |
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. The trial would be continued if there was a difference of ≥3 % between trial arms. However, the difference between ongoing pregnancy rates was <1 %
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Outcomes of IVF/ICSI cycles of women with PCOS undergoing Gonadotropin Releasing Hormone (GnRH) agonist and GnRH Antagonist fixed protocol.
Women with PCOS undergoing IVF/ICSI cycles will be evaluated by two different protocols. One arm of the study includes oral contraceptive plus GnRH agonist protocol with 150 IU FSH (standard dose) and second arm includes oral contraceptive plus GnRH Antagonist with 150 IU FSH dose and fixed 6th day starting of GnRH Antagonist.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| GnRH Agonist | Active Comparator | oral contraceptive pill and GnRH Agonist IVF/ICSI cycle |
|
| GnRH Agonist Arm | Active Comparator | Oral contraceptive pill and day 21 GnRH agonist began, Day 3 of menstruation 150 IU FSH will be started. If 3 or more follicle reach >17 mm hCG will be administered. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| To compare the IVF/ICSI outcomes of GnRH Antagonist cycle versus GnRH agonist cycle | Other | 150 IU FSH dose and OCP plus GnRH Agonist (long luteal) IVF/ICSI cycle and 150 IU FSH dose and OCP plus GnRH Antagonist (Fixed protocol) IVF/ICSI Cycle |
| Measure | Description | Time Frame |
|---|---|---|
| Ongoing pregnancy rates | Ongoing pregnancy rates measured in OCP plus GnRH Agonist and OCP plus GnRH Antagonist cycles in women with PCOS | March 2009 to June 2011 |
| clinical pregnancy rate | To evaluate the clinical pregnancy rates of both study arms | from march 2009 to july 2011 |
| Total gonadotropin use | Total gonadotropin use of both study arms | From march 2009 to June 2011 |
| Measure | Description | Time Frame |
|---|---|---|
| OHSS rates | OHSS rates in both study groups | from march 2009 to july 2011 |
| Total ongoing pregnancy rate | Total ongoing pregnacy rates of per protocol group including freezing-thawing embryo transfer cycles. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bulent Haydardedeoglu, M.D. | Baskent University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bulent Haydardedeoglu | Adana | 01120 | Turkey (Türkiye) |
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| GnRH Antagonist | Other | GnRH Antagonist cycle; 150 IU FSH and sixth day Antagonist will be administered |
|
| from march 2009 to june 2011 |
| ID | Term |
|---|---|
| C092464 | LHRH, Ac-Nal(1)-Cpa(2)-Trp(3)-Arg(6)-Ala(10)- |
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