UCSD Take Charge Study

Randomized Clinical Trial of a Weight Loss Program in Type 2 Diabetes

The purpose of the Take Charge Study is to determine among overweight and obese men and women with type 2 diabetes whether 1) participating in a commercial weight loss program promotes great weight loss and weight loss maintenance at one year compared to usual care conditions and 2) whether there is a differential weight loss response to different dietary macronutrient composition (lower carbohydrate/higher fat diet versus a higher carbohydrate/lower fat).

Inclusion Criteria:

• Aged 18 years or older
• Type 2 diabetes
• BMI 25-45 kg/m2
• Willing to participate in any of the study diet arms (higher or lower carbohydrate diet or usual care) over a one-year period
• Able to comply with all required study procedures and schedule
• Must live within the San Diego or Minneapolis area

Exclusion Criteria:

• Pregnant, breastfeeding or planning to become pregnant in the next year
• Serious medical condition or psychiatric illness
• History of having an eating disorder, food allergy or food intolerance
• Have food restrictions or requires a special diet
• Objects to frozen, processed or prepackaged foods
• Inability to be moderately physically active
• Currently enrolled in a weight loss program or another diet intervention
• Current use of weight loss medication or supplements
• Planned surgical procedure that can impact the conduct of the study
• Previous surgical procedures for weight reduction
• Does not have own transportation
• Have plans to relocate from area within 1 year
• HbA1C >11%, fasting triglycerides >600 mg/dL, serum creatinine >1.4 mg/dL (women) or 1.5 mg/dL (men) -- to be screened at baseline visit