Lifestyle Modification for Obesity-Related Type 2 Diabetes

A Randomized, Controlled Trial of a Low-Carbohydrate, Ketogenic Diet Versus a Low-Glycemic Index Diet for Obesity-Related Type 2 Diabetes

Dietary carbohydrate is the major determinant of postprandial glucose levels, and preliminary evidence suggests that low carbohydrate diets improve glycemic control when accompanied by weight loss. To determine if glycemic control can be improved by varying dietary carbohydrate during weight loss, we compared two weight loss diets with different carbohydrate levels for the treatment of obesity-related type 2 diabetes over 24 weeks in the outpatient setting.

Inclusion Criteria:

• type 2 diabetes mellitus for at least one year
• hgba1c > 6.0
• BMI from 27-50 kg/m2

Exclusion Criteria:

• Unstable medical condition
• Serious medical condition
• AST or ALT > 100
• Serum creatinine > 1.5