Granulocyte Colony Stimulating Factor (G-CSF) in Acute Liver Failure and Alcoholic Hepatitis

G-CSF in Acute Liver Failure and Alcoholic Hepatitis - A Pilot Study

Granulocyte colony stimulating factor in acute liver failure and alcoholic hepatitis

In this study 4 groups have been taken. Two groups of cases including Alcoholic patients and acute liver failure which are given G-CSF therapy and two groups of controls given standard therapy. Primary end point is to see the mobilization of CD-34 hematopoietic cells and survival. Secondary end point is to see the clinical and biochemical improvement in liver functions.

Inclusion Criteria:

• Patients with Acute Liver failure as defined by AASLD.65
• Patients with Alcoholic hepatitis defined as follows: decades of heavy alcohol use (mean intake, approximately 100 g per day).The combination of an aspartate aminotransferase level that is elevated (but <300 IU per milliliter) and a ratio of the aspartate aminotransferase level to the alanine aminotransferase level that is more than 2, a total serum bilirubin level of more than 5 mg per deciliter (86 μmol per liter), an elevated INR, and neutrophilia.

Exclusion Criteria:

• Known hypersensitivity to filgrastim

• creatinine > 150 µmol/L
• infection or hemorrhage within the last 10 days
• documented hepatocellular carcinoma
• hepatitis B,C or human immunodeficiency virus seropositivity and pregnancy