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| Name | Class |
|---|---|
| Research Center for Reproductive Medicine Villa Mafalda | UNKNOWN |
| San Raffaele University Hospital, Italy | OTHER |
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Controlled ovarian hyperstimulation with gonadotropins is an integral part of the various stimulation protocols for patients undergoing in-vitro fertilization (IVF) and other Assisted Reproductive Technologies (ART) such as intracytoplasmic sperm injection (ICSI).
The hormonal control of multiple follicular growth and maturation is a critical part of ART procedures since it maximizes the yield of embryos to be transferred, thus increasing the cumulative pregnancy rate.
Recent studies have shown the efficacy of myo-inositol (MI) supplementation as a simple and highly effective treatment in order to improve oocyte quality in patients undergoing IVF. Indeed, it was previously shown that MI follicular fluid (FF) concentration is a reliable predictor of oocyte quality. High MI concentration in the FF directly correlates with high oocyte and embryo quality.
Another stereoisomer of Inositol was successfully used into clinical practice D-chiro-inositol (DCI). In particular, DCI supplementation was used to restore ovulation in hyperglycemic PCOS patients.
In the present study we aim to compare MI versus DCI supplementation on oocyte quality of women undergoing IVF-ET
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| D-Chiro-inositol | Experimental | Patients will receive 1.2g/day of D-chiro-inositol |
|
| Myo-inositol | Active Comparator | Patients will receive 4g/day of myo-inositol |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Myo-inositol | Dietary Supplement |
| ||
| D-chito-Inositol |
| Measure | Description | Time Frame |
|---|---|---|
| number of morphologically mature oocytes | ||
| Total international units (IU) of recombinant FSH administrated | ||
| number of grade 1 embryos |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Gianfranco Carlomagno, Ph.D. | AGUNCO Obstetrics and Gynecology Centre | Principal Investigator |
| Vittorio Unfer, M.D. | AGUNCO Obstetrics and Gynecology Centre | Principal Investigator |
| Franco Lisi, M.D. | Research Center for Reproductive Medicine | Principal Investigator |
| Enrico Papaleo, M.D. | San Raffaele Hospital | Principal Investigator |
| Scott Roseff, MD | The Palm Beach Center for Reproductive Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| San Raffaele Hospital | Milan | Italy | ||||
| Research Center for Reproductive Medicine Villa Mafalda |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 12042283 | Background | Chiu TT, Rogers MS, Law EL, Briton-Jones CM, Cheung LP, Haines CJ. Follicular fluid and serum concentrations of myo-inositol in patients undergoing IVF: relationship with oocyte quality. Hum Reprod. 2002 Jun;17(6):1591-6. doi: 10.1093/humrep/17.6.1591. | |
| 21463230 | Background | Unfer V, Raffone E, Rizzo P, Buffo S. Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study. Gynecol Endocrinol. 2011 Nov;27(11):857-61. doi: 10.3109/09513590.2011.564687. Epub 2011 Apr 5. |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D007294 | Inositol |
| ID | Term |
|---|---|
| D013402 | Sugar Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D002241 | Carbohydrates |
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|
| Roma |
| Italy |
| Agunco | Rome | Italy |
| 20712264 | Background | Rizzo P, Raffone E, Benedetto V. Effect of the treatment with myo-inositol plus folic acid plus melatonin in comparison with a treatment with myo-inositol plus folic acid on oocyte quality and pregnancy outcome in IVF cycles. A prospective, clinical trial. Eur Rev Med Pharmacol Sci. 2010 Jun;14(6):555-61. |
| 19800728 | Background | Papaleo E, Unfer V, Baillargeon JP, Chiu TT. Contribution of myo-inositol to reproduction. Eur J Obstet Gynecol Reprod Biol. 2009 Dec;147(2):120-3. doi: 10.1016/j.ejogrb.2009.09.008. Epub 2009 Oct 2. |
| 18462730 | Background | Papaleo E, Unfer V, Baillargeon JP, Fusi F, Occhi F, De Santis L. RETRACTED: Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial. Fertil Steril. 2009 May;91(5):1750-1754. doi: 10.1016/j.fertnstert.2008.01.088. Epub 2008 May 7. |
| 10219066 | Background | Nestler JE, Jakubowicz DJ, Reamer P, Gunn RD, Allan G. Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome. N Engl J Med. 1999 Apr 29;340(17):1314-20. doi: 10.1056/NEJM199904293401703. |