A Study to Compare Genetic Variations of IGF-I and IGF-II

A Non-Randomized Controlled Cross-Sectional Study to Compare Genetic Variations of IGF-I and IGF-II in Patients With Moderate to Severe Dementia and Younger Family Members, in Relation to Age-Matched Unaffected Controls

The purpose of this study is to determine if insulin-like growth factors (IGF) play a role in the development of dementia, specifically Alzheimer's disease (AD). The study will compare results from genetic testing between patients with AD and two other groups: younger biological family members of the AD patients and individuals without AD matched by age to the AD patients.

Inclusion Criteria:

• Men and women between the ages of 50 and 81 years old who have a diagnosis of dementia
• Men and women who are at least 18 years old and are biologically related to the study subject with dementia
• Control subjects must not have a diagnosis of dementia and must be matched in age to the study subjects with dementia

Exclusion Criteria:

• Biological family members of the dementia patient who are either younger than 17 years of age or older than the patient with dementia
• Biological family members with a diagnosis of dementia
• Age-matched control subjects with a diagnosis of dementia