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| Name | Class |
|---|---|
| St. Olavs Hospital | OTHER |
| SINTEF Health Research | OTHER |
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The purpose of this study is to determine the effect of aerobic interval training in patients with paroxysmal or persistent atrial fibrillation, especially to see if the burden of atrial fibrillation and symptoms are reduced.
Long term endurance sport practice is associated with a higher incidence of atrial fibrillation. Moderate/light physical activity seems to be associated with a lower incidence. The underlying mechanisms are uncertain. In order to examine the effect of training in this population, the investigators will perform a randomised controlled study with aerobic interval training in patients with paroxysmal/persistent atrial fibrillation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Interval training | Experimental | Interval training |
|
| Control | No Intervention | Live as usual |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Interval training | Behavioral | Aerobic interval training will be performed with 4 times of 4 minutes intervals at an intensity of 90-95% of maximum heart rate and active pauses of 3 minutes between intervals. 3 times a week for 12 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in burden of atrial fibrillation | Burden of atrial fibrillation(number of episodes, duration(percent of the day)) continually measured, and reported by the patient. Analysed for the patients in total, with sub analysis in the groups of paroxysmal and persistent AF and in those with a low burden of atrial fibrillation vs. those with a larger burden. | Baseline and 4 weeks after ended intervention period |
| Measure | Description | Time Frame |
|---|---|---|
| Size of left atrium and ventricle | Atrial and ventricular size will be evaluated by echocardiography and MRI. | Baseline and after ended intervention period(12 weeks) |
| Blood samples | Interleukin-6, pro-BNP, d-dimer and von Willenbrands factor are measured. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jan Paal Loennechen, PhD | St. Olavs Hospital | Study Chair |
| Ulrik Wisløff, PhD | Norwegian University of Science and Technology | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Norwegian University of Science and Technology | Trondheim | Trondheim | 7491 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26733609 | Result | Malmo V, Nes BM, Amundsen BH, Tjonna AE, Stoylen A, Rossvoll O, Wisloff U, Loennechen JP. Aerobic Interval Training Reduces the Burden of Atrial Fibrillation in the Short Term: A Randomized Trial. Circulation. 2016 Feb 2;133(5):466-73. doi: 10.1161/CIRCULATIONAHA.115.018220. Epub 2016 Jan 5. |
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| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D000072696 | High-Intensity Interval Training |
| ID | Term |
|---|---|
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
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| Baseline and after ended intervention period(12 weeks) |
| Endothelial function | FMD | Baseline and after ended intervention period(12 weeks) |
| Atrial extrasystoles | Atrial extrasystoles on 48h Holter monitoring. Will alse be measured in the first week of training. | Baseline and after ended intervention period(12 weeks) |
| Ablation procedure | Duration of ablation, number of ablation points, success. | Measured during the ablation procedure (day 1) |
| Maximal oxygen uptake | Baseline and after ended intervention period(12 weeks) |
| Atrial and ventricular function | Atrial and ventricular function measured by MR and echocardiography | Baseline and after ended intervention period(12 weeks) |
| Fibrosis | Fibrosis in left atrium and left ventricle measured by MRI. | Baseline and after ended intervention period(12 weeks) |
| Quality of life | Measured with SF-36, Symptom and Severity Checklist and EHRA score of AF- related symptoms | Baseline and after ended intervention period(12 weeks) |
| Burden of atrial fibrillation in the intervention period | The intervention period is divided into 3 periods of 4 weeks each. The mean burden of atrial fibrillation(percent of time with atrial fibrillation) and number of episodes in each of those periods will be assessed to see if exercise changes the amount of fibrillation. | Week 1-4, 5-8 and 9-12 |
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |
| D009142 |
| Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |