Preopioid Versus Nonopioid in Total Knee Arthroplasty (TKA)

Acute Pain After Fast-track Total Knee Arthroplasty: Preoperative Opioid Versus Non-opioid

Observational study evaluating pain response after total knee arthroplasty (TKA) in patients taking strong, weak or no opioids preoperatively.

Inclusion Criteria:

Patients operated with elective, primary, unilateral total knee arthroplasty (TKA) (taking strong or weak opioid daily for minimum 4 weeks or opioid naive patients)

Exclusion Criteria:

• Bilateral / revision arthroplasty
• Disease affection central or peripheral nerve function
• Alcohol and medical abuse
• Daily use of glucocorticoids
• Malignancy
• BMI > 40
• Dementia or other cognitive dysfunction
• Treatment of anxiety or depression