Pregabalin and Analgesia After Laparoscopic Cholecystectomy

Preoperative Use of Pregabalin and Analgesia Levels After Laparoscopic Cholecystectomy

The purpose of this study is to evaluate how effective is the preoperative administration of pregabalin 600mg, to attenuate postoperative pain and opioids consumption after laparoscopic cholecystectomy.

Acute pain frequently occurs during the postoperative period.Not treated acute postoperative pain may predict the development of chronic pain.Recently, the analgesic effect of pregabalin, as a part of a multimodal analgesia, has been evaluated in many studies. They have shown that pregabalin may have a role in the post operative pain management, as an adjunct. Pregabalin is an anticonvulsant and anxiolytic drug, which have a more favorable pharmacokinetic profile from its predecessor gabapentin.

Acute postoperative pain after laparoscopic cholecystectomy is complex in nature. Postoperative pain is the main complaint and the primary reason for delay discharge after laparoscopic cholecystectomy.The study includes patients undergoing laparoscopic cholecystectomy.

Inclusion Criteria:

• ASA physical status I-II

Exclusion Criteria:

• Renal or hepatic insufficiency
• Alcohol or drugs abuse
• History of chronic pain or daily intake of analgesics
• Uncontrolled medical disease (hypertension, diabetes) and cardiovascular problems. Psychiatric disorders
• Inability of patients to use PCA pump
• History of intake of non-steroidal anti-inflammatory drugs the last 24 hours before surgery,use of drainage after the surgery