Analgetic Effect of Preoperative Pregabalin in Patients Undergoing Nephrectomy

Effect of Preoperative Pregabalin Administration on the Postoperative Opioid Consumption in Patients Undergoing Nephrectomy

Pregabalin 300mg or placebo are administered 1 hour preoperatively in patients undergoing elective nephrectomy. Postoperatively, patients receive a patient controlled analgesia device for self delivering opioids. Morphine consumption in the first 48 hours is documented.

Hyperalgesia is measured by von-Frey-Filaments.

Inclusion Criteria:

• patients undergoing elective nephrectomy

Exclusion Criteria:

• contraindication against pregabalin
• creatinine > 2.0 mg/dl
• GGT >165, AST >105, ALT >135
• peptic Ulcus
• haemorrhagic diathesis
• angina pectoris, myocardial infarction
• stroke
• bronchial asthma
• opioid abuse