MRI for the Non-invasive Determination of Renal Blood Flow and Renal Oxygenation
MRI for the Non-invasive Determination of Renal Blood Flow and Renal Oxygenation
Comparison of renal blood flow measurements by PAH clearance and MRI
The traditional measurement of renal blood flow in ml/min involves the collection of multiple blood and urine samples after an infusion of a drug called para-aminohippurate (PAH) is given. In this study, the investigators determine the ability of MRI to estimate renal blood flow. The primary hypothesis is that renal blood flow as measured by PAH clearance is similar to renal blood flow as estimated by MRI. The measurements by PAH clearance and MRI are both performed on the same day.
Inclusion Criteria:
In this study, the investigators will enroll 16 men and women aged ≥ 18 years with Stage II - V chronic kidney disease (CKD). In addition, the investigators will enroll 4 subjects with a glomerular filtration rate (GFR) of greater than 60 ml/min who do not have any evidence of CKD.
Exclusion Criteria:
This study excludes those not suitable for MRI or for the interventional pharmacologic procedures.