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The purpose of this study is to compare characteristics of gait and balance measured among patients with Alzheimer's disease or related disorders separated into 3 groups according to the stage of disease (i.e., pre-dementia, mild and moderate dementia stages); to determine the effects of anti-dementia drugs and vitamin D on cognitive motor abnormalities; and to establish a database at Angers University Memory Centre.
Although gait disorders are frequently associated with Alzheimer's disease and related disorders (ADRD), few studies have focused on cognitive motor effects of anti-dementia drugs and vitamin D.
The objectives of this study are to
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | Patients with Mild Cognitive Impairment |
| |
| Group 2 | Patients with Mild Alzheimer's disease or related disorders |
| |
| Group 3 | Patients with Moderate Alzheimer's disease or related disorders |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Drug intervention | Drug | before-after interventional (anti-dementia drugs and/or vitamin D) study |
|
| Measure | Description | Time Frame |
|---|---|---|
| Spatiotemporal gait parameters | baseline |
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Inclusion Criteria:
Exclusion Criteria:
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All patients of the University Memory Center of Angers University Hospital with respect to the eligibility criteria
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Cedric ANNWEILER, DM | Contact | (+33) 241354725 | ceannweiler@chu-angers.fr |
| Name | Affiliation | Role |
|---|---|---|
| Cedric ANNWEILER, MD | Memory Centre of Angers University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cédric ANNWEILER , MD | Recruiting | Angers | 49933 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27568453 | Derived | Beauchet O, Barden J, Liu-Ambrose T, Chester VL, Annweiler C, Szturm T, Grenier S, Leonard G, Bherer L, Allali G; Canadian Gait Consortium. Anti-Dementia Drugs, Gait Performance and Mental Imagery of Gait: A Non-Randomized Open-Label Trial. Drugs Aging. 2016 Sep;33(9):665-73. doi: 10.1007/s40266-016-0391-0. | |
| 24261605 | Derived |
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| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| D020235 | Gait Apraxia |
| D003072 | Cognition Disorders |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| Beauchet O, Launay CP, Allali G, Watfa G, Gallouj K, Herrmann FR, Annweiler C. Anti-dementia drugs and changes in gait: a pre-post quasi-experimental pilot study. BMC Neurol. 2013 Nov 21;13:184. doi: 10.1186/1471-2377-13-184. |
| D024801 |
| Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D020233 | Gait Disorders, Neurologic |
| D009461 | Neurologic Manifestations |
| D001072 | Apraxias |
| D011596 | Psychomotor Disorders |
| D019954 | Neurobehavioral Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |