Alzheimer's Disease and Related Disorders

Maladie d'Alzheimer et Maladies apparentées : Caractérisation Des Anomalies Cognitivo-motrices, et Des Effets Des médicaments Anti-démence et de la Vitamine D à Partir de la Mise en Place d'Une Base de données au CMRR du CHU d'Angers

The purpose of this study is to compare characteristics of gait and balance measured among patients with Alzheimer's disease or related disorders separated into 3 groups according to the stage of disease (i.e., pre-dementia, mild and moderate dementia stages); to determine the effects of anti-dementia drugs and vitamin D on cognitive motor abnormalities; and to establish a database at Angers University Memory Centre.

Although gait disorders are frequently associated with Alzheimer's disease and related disorders (ADRD), few studies have focused on cognitive motor effects of anti-dementia drugs and vitamin D.

The objectives of this study are to

• Compare characteristics of gait and balance measured among patients with ADRD separated into 3 groups according to stages of disease (i.e., pre-dementia, mild and moderate dementia stages)
• To determine the effects of anti-dementia drugs and vitamin D on cognitive motor abnormalities
• To determine whether motor abnormalities could be associated with cognitive impairments, specifically executive dysfunctions
• To establish a database at Angers University Memory Center.

Inclusion Criteria:

• All elderly patients from the University Memory Center of Angers University Hospital.
• Able to walk without any walking aid on 15 meters
• Mini-Mental Status Examination score > 10
• Being affiliated to a social security regime

Exclusion Criteria:

• Mini-Mental Status Examination score ≤ 10
• Subject suffering from pre-existing impellent disturbances
• History of cerebrovascular accident or other cerebro-spinal pathology
• Poor workmanship of the written or oral French language
• Use of walking aid such as walking frame with wheels or tricycle.
• Acute medical or surgical disease in the past 3 months
• Refusal to participate (or trustworthy person)
• Near visual acuity < 2/10