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The addition of heparin increases pregnancy outcome parameters in poor responders undergoing In Vitro Fertilisation (IVF)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Heparin, Low-Molecular-Weight group | Experimental | LMWH was administered during an IVF cycle using either the GnRH - agonist or antagonist protocol in poor responders. Drug was started at the beginning of the cycle and stopped at the time of pregnancy test if negative, or continued if pregnancy occurred until the 32th weeks of gestation |
|
| Non Heparin, Low-Molecular-Weight group | Active Comparator | IVF cycle using either the GnRH - agonist or antagonist protocol in poor responders. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Heparin, Low-Molecular-Weight | Drug | Heparin from start till hcg test |
|
| Measure | Description | Time Frame |
|---|---|---|
| no of oocytes retrieved | >2 between groups | egg recovery, 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| clinical pregnancy rate | Presence of fetal heart at transvaginal ultrasound at 6+2 gestational weeks | 2 years |
| live birth rate | >20 weeks of gestation |
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Inclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| 3rd Department of Obstetrics & Gynecology | Athens | Chaidari | 12642 | Greece |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D006495 | Heparin, Low-Molecular-Weight |
| ID | Term |
|---|---|
| D006493 | Heparin |
| D006025 | Glycosaminoglycans |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
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| no heparin | Drug |
|
| 2 years |
| cancellation rate | before ET, 2 years |
| miscarriage rate | pregnancy loss <20 weeks | 2 years |