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This study is investigating the effect of 8 weeks of orange juice supplementation on executive function in healthy older adults. The study is a controled, double-blind, crossover trial and involves a 8 week supplementation with a high flavonone orange juice and a carbohydrate-matched control. Volunteers consume 500ml of either the test juice or the control juice per day for an 8 week period. There is then an 8 week washout period before subjects proceed to the other arm of the study. Subjects are randomly assigned to either arm at the beginning of the study. Measures of cognitive function will be administered pre and post both test and control interventions. Blood pressure will also be measured and blood and urine samples will be collected to assess absorption of from the juice. A sub-sample of volunteers will undergo MRI imaging pre- and post intervention to acquire cerebral blow flow information.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High flavonone orange juice drink | Experimental |
| |
| Control orange juice drink | Placebo Comparator | Juice drink matched for sugar content |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High flavanone orange juice | Dietary Supplement | High flavonone orange juice drink. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Executive function - Attention | Assessment by human cognitive test battery delivered by computer and human operator. Assessments will be carried out at baseline and at the end of each intervention arm. | change in attention from baseline and 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma flavanones | By High performance liquid chromatography | change from baseline to 8 weeks |
| Blood pressure | Blood pressure measurement |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jeremy PE Spencer, PhD | University of Reading | Principal Investigator |
| Laurie T. Butler, PhD | University of Reading | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Reading | Reading | Berkshire | RG6 6AH. | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25733635 | Derived | Kean RJ, Lamport DJ, Dodd GF, Freeman JE, Williams CM, Ellis JA, Butler LT, Spencer JP. Chronic consumption of flavanone-rich orange juice is associated with cognitive benefits: an 8-wk, randomized, double-blind, placebo-controlled trial in healthy older adults. Am J Clin Nutr. 2015 Mar;101(3):506-14. doi: 10.3945/ajcn.114.088518. Epub 2015 Jan 14. |
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| ID | Term |
|---|---|
| D009410 | Nerve Degeneration |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Control orange juice | Dietary Supplement | Orange beverage, low flavanone content, matched for total carbohydrate content, individual sugar profile, vitamin C |
|
| change from baseline to 8 weeks |