Genetics Study of Wet Age-Related Macular Degeneration (AMD) Non-Responders to Vascular Endothelial Growth Factor (VEGF) Therapy

Genotypic Evaluation of Chronic Exudative Macular Degeneration Despite Monthly Anti-Vascular Endothelial Growth Factor (VEGF) Therapy

To obtain a genotypic analysis of patients with chronic exudative age-related macular degeneration noted to have subretinal or intraretinal edema despite continuous monthly Anti-VEGF therapy.

Inclusion Criteria:

• Ability to provide written informed consent for participation in this study
• Subjects diagnoses of neovascular AMD who are on a monthly anti-VEGF regimen (have had >10 or more ranibizumab and/or bevacizumab injections within the last year) and who still have intra-retinal or subretinal fluid as confirmed by the Investigator

Exclusion Criteria:

• Subjects with a Pigment Epithelial Detachment Exclusively
• Subjects with Serous Pigment Epithelial Detachments
• Subjects with history of the following:

idiopathic polypoidal choroidal vasculopathy

• pathologic degenerative myopia
• central serous chorioretinopathy
• familial drusen
• adult onset foveal pattern dystrophy