Genetics in Non-response to Anti-VEGF Treatment in Exudative AMD

Pharmacogenetics in Anti-VEGF Treatment Non-responders Suffering Exudative Age-related Macular Degeneration (AMD): Genetic Correlations and Intraocular Cytokine Concentrations

To assess genetic features and intraocular cytokine profiles of non-responders to anti-VEGF treatment of exudative age-related macular degeneration. Also to assess necessity and frequency of pro re nate medical re-treatment.

Inclusion Criteria:

• active subfoveal CNV related to exudative age-related macular degeneration (all subforms)
• age > 60 years
• visual acuity > 20/400
• no previous treatment for AMD

Exclusion Criteria:

• any previous AMD therapy
• other CNV types (myopic, parapapillary)
• contraindication for ranibizumab treatment
• prior study participation for AMD
• pregnancy / premenopausal women