The purpose of this study is to understand whether genes or certain factors in the environment determine how eyes will respond to Lucentis (ranibizumab) treatment. For example, whether having variants within specific genes means that a patient is likely to get better vision from treatment than another patient with different genes.

Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world. The advanced stages of the disease are characterized by the development of geographic atrophy or choroidal neovascularization, both of which result in significant loss of vision. Development of intravitreal anti-VEGF agents such as ranibizumab has significantly improved outcomes for the neovascular for of the disease. However, it is not possible to predict which individuals will respond to the treatment.

The objective of this study is to establish the association between genetic factors and treatment response to intravitreal Lucentis. This will be accomplished by SNP-genotyping participants for AMD-susceptibility and candidate angiogenesis-pathway genes, collecting environmental risk factor variables and evaluating clinical outcomes. The aim of this pharmacogenetics study will be to identify patients at the outset of their treatment that require more intensive therapy.

Inclusion Criteria:

• All AMD-related CNV lesion types will be included.
• Age >50 years
• The study eye must never have received treatment for neovascular AMD
• Visual acuity in treatment eye must be between 20/30 and 20/320 (ETDRS).

Exclusion Criteria:

• Age <50 years;
• Previous therapy in either eye for AMD or other retinal disease which may be used in the treatment of AMD;
• Choroidal neovascularization not from AMD;
• Concomitant non-AMD related maculopathy in study eye;
• Active treatment for neovascular AMD in fellow eye;
• Acuity loss or central field loss from non-AMD cause;
• Pigment epithelial detachment without evidence of CNV;
• Individuals in whom Lucentis is contraindicated;
• Participation in another clinical trial in last three months
• Pregnancy (positive pregnancy test) or lactation
• Premenopausal women not using adequate contraception
• Prior enrollment in the study
• Any other condition that the investigator believes would pose a significant hazard to the subject if the investigational therapy were initiated