Leptin Signaling in Lean and Obese Humans

Leptin Signaling in Humans

Obesity does not respond to high circulating levels of the hormone leptin. This study is aiming at finding out why this happens and open new avenues for treatment of obesity.

Ex vivo and in vitro identification and study of leptin signaling pathways in commercially available cell lines serum/ plasma samples and discarded tissues from humans.

Inclusion Criteria:

• men and women
• ages 18 to 65
• BMI ranges between 20 and 45 kg/m2

Exclusion Criteria:

• subjects requiring special diets
• history of illness other than obesity of diabetes
• taking medications known to influence glucose metabolism
• subjects with history of anaphylactic reaction or hypersensitivity to e. coli derived proteins or anesthetic agents
• women who are breastfeeding, pregnant or wanting to become pregnant
• subjects with bleeding dyscrasia or poor wound healing