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Prospective cohort study evaluating the role of leptin receptors in the bariatric surgical population compared with non obese controls. Additionally serum levels of leptin, ghrelin, motilin and PYY will be compared amongst the different BMI classes and a quality of life questionnaire completed by all participants.
The hypothesis is that obese individuals have lower leptin receptors in enterocytes which is partially responsible for the higher serum leptin levels without appropriate control of satiety.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1: Control Group | BMI <30 There are 20 controls in this group | ||
| Group 2 | BMI 30-35 There were 12 controls in this class | ||
| Group 3 | BMI 35-40 There were 9 controls in this clas | ||
| Group 4 | BMI >40 There were 9 controls in this class |
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| Measure | Description | Time Frame |
|---|---|---|
| PCR test for Leptin Receptors | Endoscopic biopsies of enterocytes will be measured via PCR | 1 week |
| Measure | Description | Time Frame |
|---|---|---|
| ELISA test for ghrelin, motilin, leptin and PYY | Blood samples collected to determine hormones via ELISA | 1 week |
| IWQOL lite questionnaire | Quality of Life questionnaire on obesity |
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Inclusion Criteria:
Exclusion Criteria:
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Males and Females undergoing endoscopy
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| Name | Affiliation | Role |
|---|---|---|
| Jennifer L Seminerio, MD | University of Pittsburgh | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Pittsburgh/UPMC Presby | Pittsburgh | Pennsylvania | 15213 | United States |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| 1 week |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |