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| ID | Type | Description | Link |
|---|---|---|---|
| 2009-A01217-50 | Registry Identifier | AFSSAPS (France) |
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| Name | Class |
|---|---|
| ROUSSELOT SAS | UNKNOWN |
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HC Group | Experimental | Group of volunteers fed with Hydrolyzed Collagen |
|
| CT Group | Active Comparator | Group of volunteers fed with wheat proteins |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| hydrolyzed collagen | Dietary Supplement | 10g/day at breakfast during 90 days |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Serum C-terminal telopeptide of type 1 collagen (CTX) | MARKERS OF BONE RESORPTION : change from Baseline (Day 0) in serum CTX at 45 days | Day 45 |
| Measure | Description | Time Frame |
|---|---|---|
| Urinary telopeptide N-terminal of type 1 collagen (NTX) | MARKERS OF BONE RESORPTION : change from Baseline (Day 0) in urinary NTX at 45 days | Day 45 |
| Serum osteocalcin | MARKERS OF BONE FORMATION : change from Baseline (Day 0) in serum osteocalcin at 45 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Robert BENAMOUZIG, MD, PhD | Centre de Recherche en Nutrition Humaine d'Ile-de-France | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CRNH - Centre de Recherche sur Volontaires - Hôpital AVICENNE | Bobigny | Seine-saint-denis | 93009 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16308135 | Background | Nomura Y, Oohashi K, Watanabe M, Kasugai S. Increase in bone mineral density through oral administration of shark gelatin to ovariectomized rats. Nutrition. 2005 Nov-Dec;21(11-12):1120-6. doi: 10.1016/j.nut.2005.03.007. | |
| 8632016 | Background | Takeuchi Y, Nakayama K, Matsumoto T. Differentiation and cell surface expression of transforming growth factor-beta receptors are regulated by interaction with matrix collagen in murine osteoblastic cells. J Biol Chem. 1996 Feb 16;271(7):3938-44. doi: 10.1074/jbc.271.7.3938. |
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| ID | Term |
|---|---|
| D010024 | Osteoporosis |
| ID | Term |
|---|---|
| D001851 | Bone Diseases, Metabolic |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D008659 | Metabolic Diseases |
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| wheat protein |
| Dietary Supplement |
10g/day at breakfast during 90 days |
|
| Day 45 |
| Serum bone alkaline phosphatase | MARKERS OF BONE FORMATION: change from Baseline (Day 0) in serum bone alkaline phosphatase at 45 days | Day 45 |
| Serum amino-terminal pro-peptide of type 1 procollagen (P1NP) | MARKERS OF BONE FORMATION : change from Baseline (Day 0) in serum P1NP at 45 days | Day 45 |
| Urinary telopeptide N-terminal of type 1 collagen (NTX) | MARKERS OF BONE RESORPTION : change from Baseline (Day 0) in urinary NTX at 90 days | Day 90 |
| Serum osteocalcin | MARKERS OF BONE FORMATION : change from Baseline (Day 0) in serum osteocalcin at 90 days | Day 90 |
| Serum bone alkaline phosphatase | MARKERS OF BONE FORMATION: change from Baseline (Day 0) in serum bone alkaline phosphatase at 90 days | Day 90 |
| Serum amino-terminal pro-peptide of type 1 procollagen (P1NP) | MARKERS OF BONE FORMATION : change from Baseline (Day 0) in serum P1NP at 90 days | Day 90 |
| Serum C-terminal telopeptide of type 1 collagen (CTX) | MARKERS OF BONE RESORPTION : change from Baseline (Day 0) in serum CTX at 90 days | Day 90 |
| 15490264 | Background | Wu J, Fujioka M, Sugimoto K, Mu G, Ishimi Y. Assessment of effectiveness of oral administration of collagen peptide on bone metabolism in growing and mature rats. J Bone Miner Metab. 2004;22(6):547-53. doi: 10.1007/s00774-004-0522-2. |
| 19895915 | Background | Guillerminet F, Beaupied H, Fabien-Soule V, Tome D, Benhamou CL, Roux C, Blais A. Hydrolyzed collagen improves bone metabolism and biomechanical parameters in ovariectomized mice: an in vitro and in vivo study. Bone. 2010 Mar;46(3):827-34. doi: 10.1016/j.bone.2009.10.035. Epub 2009 Nov 4. |
| D009750 |
| Nutritional and Metabolic Diseases |