In born VLBW infants with parental consent form signed will be given oral saline daily as placebo until discharge

In born VLBW infants with parental consent form signed will be given oral bovine lactoferrin daily until discharge

Bovine lactoferrin 200 mg/daily, given with either human milk or preterm formula

The effect of oral Lactoferrin prophylaxis on the number of culture proven sepsis attacks in very low birth weight infants during their hospitalization in neonatal intensive care unit. Sterile blood, urine and cerebrospinal fluid samples will be obtained in case of clinical symptoms of sepsis for culture.

The effect of oral Lactoferrin prophylaxis on severe necrotising enterocolitis (NEC) (Bell's stage 2 and 3) in very low birth infants during the hospitalization period in Neonatal intensive care unit. In case of feeding intolerance, abdominal distention and findings of ileus with clinical deterioration, patient will be evaluated for thrombocytopenia, metabolic acidosis, hyponatremia, blood in stool and radiological findings of NEC. Staging will be performed with clinical, laboratory and radiological findings.

FOXP3 expression on CD4+CD25+ T cells

the effect oral lactoferrin use on feeding tolerance, abdominal distension, vomiting and gastric residuals