Lactoferrin Prophylaxis in VLBW and Regulator T-cells

Oral Lactoferrin Prophylaxis to Prevent Sepsis and Necrotising Enterocolitis of Very Low Birth Weight Neonates in Neonatal Intensive Care Unit and Effect on T-regulatory Cells.

The aim of the study is to evaluate whether oral administration of 200 mg/day lactoferrin (LF) to very low birth weight infants reduces late onset sepsis and necrotising enterocolitis and the effect of LF on regulatory T cells.

Inclusion Criteria:

• Inborn infants
• Gestational age < 32 weeks
• Birth weight < 1500 g
• Parental consent

Exclusion Criteria:

• Congenital abnormalities
• Severe perinatal asphyxia