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The purpose of the study is to evaluate the effect of the Modified Atkins Diet in children and adolescents with drug-resistant epilepsy regarding seizure control, and to create a protocol for the use of the Modified Atkins Diet as a treatment for epilepsy in Norway.
The study is a prospective trial on the Modified Atkins Diet for children and adolescents with drug-resistant epilepsy. The Modified Atkins Diet is a less restrictive diet than the classical ketogenic diet, which is usually offered to this group of patients. Twenty patients between 2 and 18 years are included in the study, and the study period is 6 months. The study will be conducted at the National Centre for Child Epilepsy in Norway.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| The Modified Atkins Diet | Experimental | Treatment with the Modified Atkins Diet for 6 months |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| The Modified Atkins Diet | Other | The Modified Atkins Diet; 10 g carbohydrate per day and a high fat intake |
|
| Measure | Description | Time Frame |
|---|---|---|
| Seizure frequency | Seizure frequency is assessed after 1 month, 3 months and 6 months. | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Ambulatory EEG | 24-hours EEG before diet treatment and after 6 months on the diet. | After 6 months |
| Body Weight | Body weight was measured before diet treatment, after 1 month, 3 months and 6 months. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Morten Lossius, Phd | Oslo University Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The National Centre for Child Epilepsy | Pb. 53 | Bærum Postterminal | 1306 | Norway |
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| ID | Term |
|---|---|
| D004827 | Epilepsy |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D055423 | Diet, Ketogenic |
| ID | Term |
|---|---|
| D050528 | Diet, Carbohydrate-Restricted |
| D004035 | Diet Therapy |
| D044623 | Nutrition Therapy |
| D013812 | Therapeutics |
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| 6 months |
| Quality of life | Questionnaire assessing quality of life and life on a strict diet, assessed after one, three and six months. | 6 months |
| Ketosis | Ketosis in blood and urine measured during the whole study period | 6 months |
| Dietary records | 3-days dietary records were obtained after two and ten weeks on the diet. | 10 weeks |
| D004032 |
| Diet |
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |