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Assessment of left ventricular systolic function is the most frequent indication for routine echocardiography. Qualitative eyeball method and biplane modified Simpson's rule, both measuring radial ventricular function, are the currently recommended methods to meet this challenge. Due to the complexity of the myocardial architecture, global left ventricular function also has longitudinal and torsional components.
The aim of this study is to evaluate new echocardiographic parameters for longitudinal left ventricular function. A special focus is set on strain imaging by speckle tracking, which is a relatively new technique. Patients with different cardiac pathologies (e. g. dilated cardiomyopathy, coronary artery disease, diastolic dysfunction) will be included and compared to healthy individuals.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Healthy individuals without structural heart disease | ||
| CAD | Patients with coronary artery disease | ||
| DCM | Participants with dilated cardiomyopathy | ||
| HNCM | Patients with hypertrophic non-obstructive cardiomyopathy | ||
| HOCM | Patients with hypertrophic obstructive cardiomyopathy | ||
| RCM | Patients with restrictive cardiomyopathy | ||
| Amyloidosis | Patients with cardiac manifestation of amyloidosis | ||
| HFPEF | Patients with heart failure with preserved ejection fraction (diastolic heart failure) |
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| Measure | Description | Time Frame |
|---|---|---|
| left ventricular longitudinal systolic strain (LV-LSS) in all patients | left ventricular longitudinal systolic strain (LV-LSS) is measured in all patients by speckle tracking strain imaging | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| mitral annular plane systolic excursion (MAPSE) in all patients | MAPSE is measured by M-Mode echocardiography | 2 years |
| mitral annular systolic velocity (MASV) in all patients | MASV is derived from tissue doppler |
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Inclusion Criteria:
Exclusion Criteria:
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Healthy individuals and patients with various cardiac pathologies, who undergo routine echocardiography at our department
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| Name | Affiliation | Role |
|---|---|---|
| Matthias Aurich, M.D. | Heidelberg University | Principal Investigator |
| Derliz Mereles, M.D. | Heidelberg University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Heidelberg | Heidelberg | 69120 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27013249 | Derived | Aurich M, Keller M, Greiner S, Steen H, Aus dem Siepen F, Riffel J, Katus HA, Buss SJ, Mereles D. Left ventricular mechanics assessed by two-dimensional echocardiography and cardiac magnetic resonance imaging: comparison of high-resolution speckle tracking and feature tracking. Eur Heart J Cardiovasc Imaging. 2016 Dec;17(12):1370-1378. doi: 10.1093/ehjci/jew042. Epub 2016 Mar 24. |
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| ID | Term |
|---|---|
| D018754 | Ventricular Dysfunction |
| D009202 | Cardiomyopathies |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| 2 years |
| diastolic left ventricular function in all patients | Diastolic function is assesed by mitral inflow, mitral annulus velocity, pulmonary vein flow and velocity of flow progression. | 2 years |
| pulmonary artery systolic pressure (PASP) in all patients | PASP is derived from Tricuspid valve regurgitation velocity | 2 years |
| left ventricular ejection fraction (LVEF) in all patients | EF is measured by modified Simpson's rule (biplane) | 2 years |