Changes in Endothelial Function and Biomarkers in African Americans (AA) With Metabolic Syndrome

Changes in Central Aortic Pressure, Endothelial Function and Biomarkers in African Americans With Cardiometabolic Syndrome: Comparison of Amlodipine/Olmesartan Versus Hydrochlorothiazide/Losartan

The purpose of the study is to compare the effects of Azor (a combination of amlodipine and olmesartan) with Hyzaar ( a combination of losartan and hydrochlorothiazide) on the thin lining on the inside of blood vessels. These cells help keep blood vessels healthy and blood pressure normal.

Participants must be 18-75 years of age, African American, and have a combination of high blood pressure, insulin resistance (Type 2 Diabetes), low HDL cholesterol levels or obesity.

Inclusion Criteria:

• African American
• Hypertension and one of the following:
• Fasting glucose > 100 mg/dl
• HgA1C> 6.0 %
• Plasma triglycerides >150
• HDL cholesterol < 40 mg/dl in men or < 50 mg/dl in women

Exclusion Criteria:

• History of Heart failure
• use of insulin
• non-dominant arm circ > 50 cm.