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The purpose of this study is to test the effectiveness of cognitively stimulating activities for resolving delirium in people with dementia.
The primary aim in this RCT is to test the efficacy of Recreational Stimulation for Elders as a Vehicle to resolve DSD (RESERVE- DSD). The investigators will randomize 256 subjects, newly admitted to post acute care, to intervention (RESERVE-DSD) or control (usual care). Intervention subjects will receive 30-minute sessions of tailored cognitively stimulating recreational activities for up to 30 days. The investigators hypothesize that subjects who receive RESERVE-DSD will have: decreased severity and duration of delirium; greater gains in attention, orientation, memory, abstract thinking, and executive functioning; and greater gains in physical function compared to subjects with DSD who receive usual care. The investigators will also evaluate potential moderators of intervention efficacy (lifetime of complex mental activities and APOE status). The secondary aim is to describe the costs associated with RESERVE-DSD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Usual care | No Intervention | Participants receive standard clinical care | |
| Treatment | Experimental | Behavioral: cognitive stimulation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cognitive Stimulation | Behavioral | Thirty minutes of cognitive stimulation delivered daily for thirty minutes. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Confusion Assessment Method | Averaged over 30 days or until discharge, whichever comes first | |
| Delirium Rating Scale | Averaged over 30 days or until discharge, whichever comes first |
| Measure | Description | Time Frame |
|---|---|---|
| Attention | Averaged over 30 days or until discharge, whichever comes first | |
| Memory | Averaged over 30 days or until discharge, whichever comes first | |
| Abstract Thinking |
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Inclusion Criteria:
Exclusion Criteria:
severe vision or hearing problems
diagnosis of
life expectancy < 6 months
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| Name | Affiliation | Role |
|---|---|---|
| Ann M Kolanowski, PhD, RN | Penn State University | Principal Investigator |
| Donna M Fick, PhD, RN | Penn State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Crest Nursing Home | Bellefonte | Pennsylvania | 16823 | United States | ||
| The Meadows Manor |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22513181 | Background | Yevchak A, Steis M, Diehl T, Hill N, Kolanowski A, Fick D. Managing delirium in the acute care setting: a pilot focus group study. Int J Older People Nurs. 2012 Jun;7(2):152-62. doi: 10.1111/j.1748-3743.2012.00324.x. Epub 2012 Apr 18. | |
| 21569370 | Background | Kolanowski AM, Fick DM, Litaker MS, Clare L, Leslie D, Boustani M. Study protocol for the recreational stimulation for elders as a vehicle to resolve delirium superimposed on dementia (Reserve For DSD) trial. Trials. 2011 May 11;12:119. doi: 10.1186/1745-6215-12-119. |
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| ID | Term |
|---|---|
| D003693 | Delirium |
| D003704 | Dementia |
| ID | Term |
|---|---|
| D003221 | Confusion |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| Averaged over 30 days or until discharge, whichever comes first |
| Orientation | Averaged over 30 days or until discharge, whichever comes first |
| Executive Function | Averaged over 30 days or until discharge, whichever comes first |
| Physical Function | Averaged over 30 days or until discharge, whichever comes first |
| Dallas |
| Pennsylvania |
| 18612 |
| United States |
| Spring Creek Rehabilitation and Nursing Center | Harrisburg | Pennsylvania | 17111 | United States |
| Windy Hill Village | Philipsburg | Pennsylvania | 16866 | United States |
| Mountain View | Scranton | Pennsylvania | 18505 | United States |
| Brookline Nursing & Rehabilitation Center | State College | Pennsylvania | 16801 | United States |
| Hearthside Nursing and Rehabilitation Center | State College | Pennsylvania | 16801 | United States |
| Hearthside Nursing Home | State College | Pennsylvania | 16801 | United States |
| The Village at Penn State | State College | Pennsylvania | 16803 | United States |
| 21053841 | Background | Kolanowski AM, Fick DM, Clare L, Steis M, Boustani M, Litaker M. Pilot study of a nonpharmacological intervention for delirium superimposed on dementia. Res Gerontol Nurs. 2011 Jul;4(3):161-7. doi: 10.3928/19404921-20101001-98. Epub 2010 Oct 29. |
| 20336555 | Background | Kolanowski AM, Fick DM, Clare L, Therrien B, Gill DJ. An intervention for delirium superimposed on dementia based on cognitive reserve theory. Aging Ment Health. 2010 Mar;14(2):232-42. doi: 10.1080/13607860903167853. |
| 22904596 | Background | Hill NL, Kolanowski AM, Gill DJ. Plasticity in Early Alzheimer's Disease: An Opportunity for Intervention. Top Geriatr Rehabil. 2011 Oct;27(4):257-267. doi: 10.1097/tgr.0b013e31821e588e. |
| 23066682 | Background | Kolanowski AM, Fick DM, Yevchak AM, Hill NL, Mulhall PM, McDowell JA. Pay attention! The critical importance of assessing attention in older adults with dementia. J Gerontol Nurs. 2012 Nov;38(11):23-7. doi: 10.3928/00989134-20121003-05. Epub 2012 Oct 15. |
| 22652933 | Background | Kolanowski A, Bossen A, Hill N, Guzman-Velez E, Litaker M. Factors associated with sustained attention during an activity intervention in persons with dementia. Dement Geriatr Cogn Disord. 2012;33(4):233-9. doi: 10.1159/000338604. Epub 2012 May 31. |
| 23859475 | Background | Kolanowski A, Mulhall P, Yevchak A, Hill N, Fick D. The triple challenge of recruiting older adults with dementia and high medical acuity in skilled nursing facilities. J Nurs Scholarsh. 2013 Dec;45(4):397-404. doi: 10.1111/jnu.12042. Epub 2013 Jul 16. |
| 24121464 | Background | Yevchak AM, Fick DM, McDowell J, Monroe T, May K, Grove L, Kolanowski AM, Waller JL, Inouye SK. Barriers and facilitators to implementing delirium rounds in a clinical trial across three diverse hospital settings. Clin Nurs Res. 2014 Apr;23(2):201-15. doi: 10.1177/1054773813505321. Epub 2013 Oct 11. |
| 24856271 | Result | Kolanowski AM, Hill NL, Kurum E, Fick DM, Yevchak AM, Mulhall P, Clare L, Valenzuela M. Gender differences in factors associated with delirium severity in older adults with dementia. Arch Psychiatr Nurs. 2014 Jun;28(3):187-92. doi: 10.1016/j.apnu.2014.01.004. Epub 2014 Feb 5. |
| 24635006 | Result | Hill NL, Kolanowski AM, Fick D, Chinchilli VM, Jablonski RA. Personality as a moderator of cognitive stimulation in older adults at high risk for cognitive decline. Res Gerontol Nurs. 2014 Jul-Aug;7(4):159-70. doi: 10.3928/19404921-20140311-01. Epub 2014 Mar 18. |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |