Study of Tolerance to Oral Peanut

Efficacy and Safety of High-dose Peanut Oral Immunotherapy With Factors Predicting Outcome

Open pilot study of peanut oral immunotherapy in 22 children with peanut allergy

Background Peanut allergy is severe and rarely resolves.

Objective To test the efficacy and safety of a new oral immunotherapy protocol for peanut allergy.

Method 22 peanut-allergic children will undergo oral challenge. Oral immunotherapy will be administered by gradual updosing with 2-weekly increments (8-38w) to 800mg protein (5 peanuts/day) followed by 30-weeks maintenance. Oral challenge will be repeated after 6 and 30 weeks maintenance.

Inclusion Criteria:

• Peanut allergy defined by oral challenge

Exclusion Criteria:

• Major immunodeficiency