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Cocaine addiction is a serious disease. Nowadays we still have no efficient method reducing craving and extending the abstinence period of this patients during treatment.
The aim of this study is to evaluate reduction if craving and other parameters related to addiction within this group of patients through a treatment with transcranial magnetic stimulation.
Patients are going to submitted do a course of rTMS of one month, each session up to 15 minutes.
After the rTMS they are going to be offered cognitive therapy to prevent relapse.
The area stimulated is the dorso-lateral prefrontal cortex. This technique was employed in previous studies and the risks are insignificant.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Transcranial Magnetic Stimulation | Active Comparator | Cocaine addicted will receive a 20 day TMSr to right dorsolateral prefrontal cortex. |
|
| Transcranial Magnetic Stimlation | Sham Comparator | cocaine addicted will receive a 20 day sham TMSr to right dorsolateral prefrontal cortex |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial Magnetic Stimulation | Procedure | 5 Hz, 120 % motor threshold, intertrain interval 20s, number of pulses in train 50. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Minnesota Cocaine Craving Scale(MCCS) | Reduction on the scores of MCCS | 2 months |
| Measure | Description | Time Frame |
|---|---|---|
| Barrat Impulsiveness Scale vers 11 ( BIS 11) | Reduction of scores of BIS 11. | 2 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Philip L Ribeiro, MD | Contact | 551130698159 | philipribeiro@usp.br |
| Name | Affiliation | Role |
|---|---|---|
| Philip L Ribeiro, MD | Post Graduate Student Department of Brain Stimulation - IPQ - HC FMUSP | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department and Institute of Psychiatry, General Hospital, University of Sao Paulo medical school | Recruiting | São Paulo | São Paulo | 05403010 | Brazil |
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| Transcranial Magnetic Stimulation | Procedure | Cocaine addicted will receive 20 sham TMSr |
|
|
| ID | Term |
|---|---|
| D019970 | Cocaine-Related Disorders |
| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D050781 | Transcranial Magnetic Stimulation |
| ID | Term |
|---|---|
| D055909 | Magnetic Field Therapy |
| D013812 | Therapeutics |
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