The study evaluates the efficacy of 3 weeks of repetitive transcranial magnetic stimulation (rTMS), 5 sessions/weekly, in reducing cocaine consumption immediately after and within the 8 weeks following the treatment in addicted patients with cocaine use disorders (CUD) versus placebo.

40 patients are expected and randomized in two groups: 20 patients with active rTMS and 20 with placebo rTMS.

Visit 1: 15 days (3 weeks of 5 consecutive daily sessions and 2 days of rest) 15Hz rTMS is performed during the following days in addition to a biweekly urine drug test and VAS evaluation.

Visit 2: Changes from baseline to week 8 in cocaine intake. Evaluation of craving and of other assessments like mood and quality of life.

Inclusion Criteria:

• male and female patients between 18 and 65 years of age
• patients who meet the criteria for CUD reported in the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-V)
• positivity to cocaine use, determined via an urine drug test
• patients who are able to provide a written informed consent, after being notified about the treatment and the study protocol

Exclusion Criteria:

• major depression disorder, schizophrenia, bipolar disorder or other psychosis that meet the diagnostic criteria of the DSM-V
• illiteracy or cognitive impairment disorders
• women who are pregnant or lactating
• other medical diseases that contraindicate rTMS treatment such as epilepsy
• presence of devices, i.e. pace-makers or cochlear prosthesis
• previous rTMS treatments in order to avoid confounding factors
• patients who can not provide the written informed consent
• DSM-V substance use disorders other than CUD. Only tobacco smoke is allowed to be recruited in the study protocol.