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| Name | Class |
|---|---|
| Canada, Young Men's Christian Association (YMCA) | UNKNOWN |
| Parkinson Society Canada | OTHER |
| Canada, Sun Life Financial | UNKNOWN |
| Canadian Institutes of Health Research (CIHR) |
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The purpose of this study is 1.) to determine if sensory attention focused exercise is an effective management strategy for Parkinson's disease, and 2.) to identify if the benefits are a result of strength gains.
Currently, there is no cure for Parkinson's disease (PD) and although medication offers symptom reduction, there are many negative side effects associated with medication use. Thus, there has been an increased emphasis on exercise interventions for symptom reduction. Recent research has shown that both sensory attention focused exercise (SAFEx) and strength training interventions improved disease severity more so than other exercise interventions (such as aerobic, aquatic and no exercise). Upon closer examination, SAFEx showed further symptom improvements than the strength training program. Thus exists the need to further examine SAFEx using a standardized protocol - a single-blind randomized double-crossover trial - that has been used sparingly in exercise interventions. In addition, the 30-second chair stand has been implemented into the testing protocol, as it has been shown to be a reliable measurement of functional strength for older adults. This test was implemented in order to identify the functional strength gains, if any, that are associated with SAFEx. It is hypothesized that the SAFEx intervention will improve disease symptoms in PD, and that the results will not be due to strength gains.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A | Experimental | Participants received 12 weeks of Sensory Attention Focused Exercise, then received 12 weeks of no exercise. |
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| Group B | Experimental | Participants received no treatment for 12 weeks, then received Sensory Attention Focused Exercise for 12 weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sensory Attention Focused Exercise (SAFEx) | Other | Consisted of 12 weeks for SAFEx intervention, 3 times a week for an hour each session. Participants complete dynamic balance activities and a variety of seated stretches and range of motion activities. Participants are cued to focus on sensation and proprioception of limbs. Group A received SAFEx for 12 weeks then received no treatment for 12 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| Unified Parkinson's Disease Rating Scale (UPDRS) III (motor score) | Assessment of patient's disease severity, completed by a blinded certified clinician. | Baseline, 12 weeks and 24 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Timed up and go | Participants stand out of a chair, walk 3 meters, turn around and sit back down. This task is timed. | Baseline, 12 weeks and 24 weeks |
| 30 second chair stand | Participants instructed to stand from a seated position as many times as possible in 30 seconds. Number of completed stands is recorded. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Quincy J Almeida, Ph.D | Sun Life Financial Movement Disorders Research and Rehabilitation Centre | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sun Life Financial Movement Disorders Research and Rehabilitation Centre | Waterloo | Ontario | N2L 3J4 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19373930 | Background | Sage MD, Almeida QJ. Symptom and gait changes after sensory attention focused exercise vs aerobic training in Parkinson's disease. Mov Disord. 2009 Jun 15;24(8):1132-8. doi: 10.1002/mds.22469. | |
| 19938164 | Background | Sage MD, Almeida QJ. A positive influence of vision on motor symptoms during sensory attention focused exercise for Parkinson's disease. Mov Disord. 2010 Jan 15;25(1):64-9. doi: 10.1002/mds.22886. |
| Label | URL |
|---|---|
| The Sun Life Movement Disorders Research and Rehabilitation Centre, based out of Wilfrid Laurier University, facilitates relevant research on Parkinson's disease. | View source |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| OTHER_GOV |
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|
| Sensory Attention Focused Exercise (SAFEx) | Other | Consisted of 12 weeks for SAFEx intervention, 3 times a week for an hour each session. Participants complete dynamic balance activities and a variety of seated stretches and range of motion activities. Participants are cued to focus on sensation and proprioception of limbs. Group B received no treatment for 12 weeks, then received SAFEx for 12 weeks. |
|
| Baseline, 12 weeks and 24 weeks |
| Unified Parkinson's Disease Rating Scale (UPDRS) - I and II (self report of mentation, depression, and activities of daily living). | Participants complete a self-report questionnaire, and rank how they are feeling. | Baseline, 12 weeks and 24 weeks |
| Grooved Pegboard | Participants must place and remove 25 pegs as fast as possible using a standard Grooved Pegboard. Participants are timed. | Baseline, 12 weeks and 24 weeks |
| Step Length | Measured using GAITRite software. | Baseline, 12 weeks and 24 weeks |
| Velocity | Assessed using GAITRite software. | Baseline, 12 weeks and 24 weeks |
| Step to Step Length Variability | Assessed using GAITRite software. | Baseline, 12 weeks and 24 weeks |
| 17229744 | Background | Nieuwboer A, Kwakkel G, Rochester L, Jones D, van Wegen E, Willems AM, Chavret F, Hetherington V, Baker K, Lim I. Cueing training in the home improves gait-related mobility in Parkinson's disease: the RESCUE trial. J Neurol Neurosurg Psychiatry. 2007 Feb;78(2):134-40. doi: 10.1136/jnnp.200X.097923. |
| 8145901 | Background | Comella CL, Stebbins GT, Brown-Toms N, Goetz CG. Physical therapy and Parkinson's disease: a controlled clinical trial. Neurology. 1994 Mar;44(3 Pt 1):376-8. doi: 10.1212/wnl.44.3_part_1.376. |
| 38588457 | Derived | Ernst M, Folkerts AK, Gollan R, Lieker E, Caro-Valenzuela J, Adams A, Cryns N, Monsef I, Dresen A, Roheger M, Eggers C, Skoetz N, Kalbe E. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2024 Apr 8;4(4):CD013856. doi: 10.1002/14651858.CD013856.pub3. |
| 36602886 | Derived | Ernst M, Folkerts AK, Gollan R, Lieker E, Caro-Valenzuela J, Adams A, Cryns N, Monsef I, Dresen A, Roheger M, Eggers C, Skoetz N, Kalbe E. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2023 Jan 5;1(1):CD013856. doi: 10.1002/14651858.CD013856.pub2. |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |