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| ID | Type | Description | Link |
|---|---|---|---|
| 5R01NS028127-16 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Neurological Disorders and Stroke (NINDS) | NIH |
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The goal of this trial is to compare the effect of two different exercise programs on neuro-physiological, motor, functional, and quality-of-life issues in individuals with Parkinson's disease to determine which program is most beneficial.
Parkinson's disease (PD) negatively affects the quality of life for a million individuals in the United States. While medication and surgery are the most effective treatments for PD, physicians and people with PD often delay using these treatments because of their considerable adverse side effects. Until a cure for PD is discovered, there is a compelling need to develop interventions that provide relief of symptoms without causing negative side effects.
Recent research suggests that exercise may provide symptom relief in some characteristics of PD. While various exercise interventions appear to effectively improve motor, functional, and quality-of-life issues, the research is mixed regarding the nature, extent and duration of these improvements. Understanding how multiple characteristics of PD change and whether they can be modified by different exercise programs is essential to determining if an exercise program is clinically effective for PD.
This study is designed to compare the initial (six months), and then long-term (2 years) effect that 2 different exercise programs (progressive resistance program or flexibility program) have on neuro-physiological, motor, functional, and quality-of-life issues in individuals with Parkinson's disease. The goal is to determine which program is most beneficial. Results from this study will be used to determine which exercise program produces the most beneficial effects on neuro-physiological, motor, functional and quality-of-life measures.
NOTE: Recruitment for Parkinson's disease participants is now closed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Progressive resistance training | Active Comparator | Subjects will perform between 60 and 90 minutes of progressive resistance training two times a week for two years at a local gym. These sessions will be supervised by a personal trainer two times a week for the first six months of training and then once a week for the remaining 18 months of training. |
|
| Modified Fitness Counts | Active Comparator | Subjects will perform between 60 and 90 minutes of modified Fitness Counts two times a week for two years at a local gym. These sessions will be supervised by a personal trainer two times a week for the first six months of training and then once a week for the remaining 18 months of training. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Progressive resistance training | Behavioral | Exercise twice a week for 2 years doing either progressive resistance training. The The PRE program consisted of 11 strengthening exercises: chest press, latissimus pull downs, reverse flys, double leg press, hip extension, shoulder press, biceps curl, rotary calf (ankle plantar flexion), triceps extension, seated quadriceps extension and back extension. |
| Measure | Description | Time Frame |
|---|---|---|
| Off Medication UPDRS Part III, Motor Subscale Score | UPDRS part III, is an observer rated clinical measure of motor signs of PD. It is used as a measure of severity of motor signs. We measured this at baseline, 6 , 18 and 24 months. This is a ordinal scale of 0-4 which has 27 items which measures slowness of movement (Bradykinesia), Tremor, Rigidity (muscle stiffness) and postural instabilty. The total value for UPDRS part III scale which ranges from 0 to 108, with a larger number indicating a higher level of impairment. | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Measure | Description | Time Frame |
|---|---|---|
| On Medication UPDRS-III | UPDRS part III, is an observer rated clinical measure of motor signs of PD. It is used as a measure of severity of motor signs. We measured this at baseline, 6 , 18 and 24 months. This is a ordinal scale of 0-4 which has 27 items which measures slowness of movement (Bradykinesia), Tremor, Rigidity (muscle stiffness) and postural instabilty. The total value for the UPDRS part III scale which ranges from 0 to 108, with a larger number indicating a higher level of impairment. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Daniel Corcos, Ph.D. | Northwestern University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Physical Therapy Department at the University of Illinois at Chicago | Chicago | Illinois | 60612 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38588457 | Derived | Ernst M, Folkerts AK, Gollan R, Lieker E, Caro-Valenzuela J, Adams A, Cryns N, Monsef I, Dresen A, Roheger M, Eggers C, Skoetz N, Kalbe E. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2024 Apr 8;4(4):CD013856. doi: 10.1002/14651858.CD013856.pub3. | |
| 36602886 | Derived | Ernst M, Folkerts AK, Gollan R, Lieker E, Caro-Valenzuela J, Adams A, Cryns N, Monsef I, Dresen A, Roheger M, Eggers C, Skoetz N, Kalbe E. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2023 Jan 5;1(1):CD013856. doi: 10.1002/14651858.CD013856.pub2. |
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Patients were 50 to 67 years; on stable PD meds; and can walk for 6 minutes. Patients were ineligible if they had a neurological history other than PD; significant arthritis; failed the Physical Activity Readiness Questionnaire; had cognitive impairment (indicated by Mini-Mental State Examination score); actively exercising; or had surgery for PD.
Patients with Parkinson's disease, confirmed by a Movement Disorders specialist, were self-referred or recruited from Rush University Medical Center (RUMC) between 9/2007 and 7/2011 for PD subjects. Patients were evaluated at the University of Illinois at Chicago (UIC).
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| ID | Title | Description |
|---|---|---|
| FG000 | 1 Progressive Resistance Training | Subjects performed between 60 and 90 minutes of progressive resistance training two times a week for two years at a local gym. These sessions were supervised by a personal trainer two times a week for the first six months of training and then once a week for the remaining 18 months of training. Exercises included progressive resistance training. Participants exercised twice a week for 2 years doing progressive resistance training. |
| FG001 | 2 Modified Fitness Counts | Subjects performed between 60 and 90 minutes of flexibility training two times a week for two years at a local gym. These sessions were supervised by a personal trainer two times a week for the first six months of training and then once a week for the remaining 18 months of training. Exercise inlcuded flexibility training. Participants exercised twice a week for 2 years doing flexibility training. |
| Title | Milestones | Reasons Not Completed | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
|
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| ID | Title | Description |
|---|---|---|
| BG000 | 1 Progressive Resistance Training | 25 PD Subjects performed between 60 and 90 minutes of progressive resistance training two times a week for two years at a local gym. These sessions were supervised by a personal trainer two times a week for the first six months of training and then once a week for the remaining 18 months of training. Exercises included progressive resistance training. Participants exercised twice a week for 2 years doing progressive resistance training. |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Off Medication UPDRS Part III, Motor Subscale Score | UPDRS part III, is an observer rated clinical measure of motor signs of PD. It is used as a measure of severity of motor signs. We measured this at baseline, 6 , 18 and 24 months. This is a ordinal scale of 0-4 which has 27 items which measures slowness of movement (Bradykinesia), Tremor, Rigidity (muscle stiffness) and postural instabilty. The total value for UPDRS part III scale which ranges from 0 to 108, with a larger number indicating a higher level of impairment. | Posted | Mean | Standard Deviation | units on a scale | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
|
SAE's and AE's were collected for 2 years for each study participant.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | 1 Progressive Resistance Training | Subjects performed between 60 and 90 minutes of progressive resistance training two times a week for two years at a local gym. These sessions were supervised by a personal trainer two times a week for the first six months of training and then once a week for the remaining 18 months of training. Exercises included progressive resistance training. Participants exercised twice a week for 2 years doing progressive resistance training. |
| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| Passed away | Injury, poisoning and procedural complications | Non-systematic Assessment | Passed away after getting hit by a car |
| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| Wrist pain | Musculoskeletal and connective tissue disorders | Non-systematic Assessment | Wrist pain while during MVC during testing |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Daniel Corcos, PhD | Northwestern University | 708-214-5454 | daniel.corcos@northwestern.edu |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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|
| Modified Fitness Counts | Behavioral | The modified Fitness Counts program was taken from Chapters 2 and 3 of the Parkinson's disease: Fitness Counts booklet and focused on non-progressive stretching, strengthening and balance exercises. |
|
| obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| L-dopa equivalent-mg/Day | This was the equivalent amount of dopamine (mg/day) each subject was prescribed based upon all of their PD medications. | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Elbow Flexion Strength | This is the MVC for elbow flexion | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Ankle Plantar Flexion Strength | This is a measure of the MVC for ankle plantar flexion strength | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Elbow Extension Strength | This is a measure of the MVC for elbow extension | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Ankle Dorsiflexion Strength | This is a measure of the MVC for ankle dorsiflexion | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Percentage of Agonist EMG Signal Contained in the 0-5, 5-15, 15-30, and 35-50 Hz Frequency Bins During Isometric Contractions | This is a measure of the percentage of the EMG signal that is contained in different frequency bins during a MVC (elbow flexion/extension; ankle DF/PF), a 50% of MVC elbow fleixon contraction, and a 5 NM elbow flexion contraction. | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| The Integral of the First Agonist Burst | The Integral of the first agonist EMG signal from onset of the agonist EMG signal until peak velocity | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Magnitude of the First 30 ms of the Agonist Burst | The integral of the first 30 msec of the agonist EMG. | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Magnitude of the Antagonist Burst | the area under the rectified antagonist signal form agonist EMG onset until the end of movement. This reflects the amount of antagonist activation during movement. | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Magnitude of the Agonist Burst | Magnitude of the agonist burst reflects the amount of agonist activation during movement. | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Duration of First Agonist Burst | Time in (ms) for the duration of the first agonist burst during a 72 degree elbow flexion movement and also the percentage of agonist EMG bursts until peak velocity | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Number of Agonist Bursts | This is the number of agonist bursts prior to peak velocity. | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Co-contraction During Limb Acceleration | the amount of agonist and antagonist activity present during limb acceleration. | Obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Qant | The integral of the antagonist EMG signal from the onset of the agonist EMG to the end of the movement | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Time to Peak Velocity | Time of the onset of the movement to peak velocity. | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Peak Movement Velocity | This is how fast an individual can perform a 72 degree elbow flexion movement | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Relaxation Time | Time for a subject to passively relax their muscle after performing and isometric contraction to 50% of their MVC | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Rise Time | This is the time is takes for an individual to go for rest to a 50% of a MVC contraction as fast as possible. | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Spatiotemporal Gait Analysis | Spatiotemporal gait analysis using a pressure sensitive walk way allow for measurement of gait velocity, step length, single and double limb support time, cadence, ect. | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Distance Walked in 6 Minutes | This is how far an individual can walk in 6 minutes | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Modified Physical Performance Test | This is an overall measure of physical fuction | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Time on the Timed up and go Test | This is the time it takes an individual to get up from a chair, walk 3 meters, turn around and walk back. | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Berg Balance Scale Score | This is a overall measure of balance | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Functional Reach | The distance one can reach forward without taking a step. | Obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Cognitive Function - Stroop Test | This is a test of cognitive function. This test requires individuals to first say as many colors as they can under three different test conditions. | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Cognitive Function - Brief Test of Attention | This is a cognitive test of an individuals ability to remember number. It is a test of working memory. | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Cognitive Function - Digit Span Forward/Backward | This tests a persons ability to remember that were read to them both forward and then backwards. | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Parkinson 's Disease Quality of Life | PDQ-39 is a composite measure of quality of life in individuals with Parkinson's Disease. | Obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Epworth Sleepiness Scale | The Epworth Sleepiness Scale is used to determine the level of daytime sleepiness. | Obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Beck's Depression Inventory | This is a self-report rating inventory that measures characteristic attitudes and symptoms of depression. | Obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| 50 ft Walk Time | Time it takes to walk 50 feet | Obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| 50 Foot Walk Speed | The speed that aerson walks over 50 feet | Obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| 5 Time Sit to Stand | The time it takes to stand up and sit down five times | Obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| 26148003 | Derived | David FJ, Robichaud JA, Leurgans SE, Poon C, Kohrt WM, Goldman JG, Comella CL, Vaillancourt DE, Corcos DM. Exercise improves cognition in Parkinson's disease: The PRET-PD randomized, clinical trial. Mov Disord. 2015 Oct;30(12):1657-63. doi: 10.1002/mds.26291. Epub 2015 Jul 6. |
| Medical complications |
|
| Underwent DBS |
|
| Death |
|
| Lost to Follow-up |
|
| Did not want to come off medication |
|
| BG001 | 2 Flexibility Training | 25 PD subjects performed between 60 and 90 minutes of flexibility training two times a week for two years at a local gym. These sessions were supervised by a personal trainer two times a week for the first six months of training and then once a week for the remaining 18 months of training. Exercise inlcuded flexibility training. Participants exercised twice a week for 2 years doing flexibility training. |
| BG002 | Total | Total of all reporting groups |
| years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
Baseline Assessment - off medication UPDRS part III, motor subscale score |
|
|
| Secondary | On Medication UPDRS-III | UPDRS part III, is an observer rated clinical measure of motor signs of PD. It is used as a measure of severity of motor signs. We measured this at baseline, 6 , 18 and 24 months. This is a ordinal scale of 0-4 which has 27 items which measures slowness of movement (Bradykinesia), Tremor, Rigidity (muscle stiffness) and postural instabilty. The total value for the UPDRS part III scale which ranges from 0 to 108, with a larger number indicating a higher level of impairment. | Posted | Mean | Standard Deviation | units on a scale | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
|
|
|
| Secondary | L-dopa equivalent-mg/Day | This was the equivalent amount of dopamine (mg/day) each subject was prescribed based upon all of their PD medications. | Posted | Mean | Standard Deviation | mg/day | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
|
|
|
| Secondary | Elbow Flexion Strength | This is the MVC for elbow flexion | Not Posted | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Ankle Plantar Flexion Strength | This is a measure of the MVC for ankle plantar flexion strength | Not Posted | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Elbow Extension Strength | This is a measure of the MVC for elbow extension | Not Posted | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Ankle Dorsiflexion Strength | This is a measure of the MVC for ankle dorsiflexion | Not Posted | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Percentage of Agonist EMG Signal Contained in the 0-5, 5-15, 15-30, and 35-50 Hz Frequency Bins During Isometric Contractions | This is a measure of the percentage of the EMG signal that is contained in different frequency bins during a MVC (elbow flexion/extension; ankle DF/PF), a 50% of MVC elbow fleixon contraction, and a 5 NM elbow flexion contraction. | Not Posted | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | The Integral of the First Agonist Burst | The Integral of the first agonist EMG signal from onset of the agonist EMG signal until peak velocity | Not Posted | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Magnitude of the First 30 ms of the Agonist Burst | The integral of the first 30 msec of the agonist EMG. | Not Posted | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Magnitude of the Antagonist Burst | the area under the rectified antagonist signal form agonist EMG onset until the end of movement. This reflects the amount of antagonist activation during movement. | Not Posted | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Magnitude of the Agonist Burst | Magnitude of the agonist burst reflects the amount of agonist activation during movement. | Not Posted | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Duration of First Agonist Burst | Time in (ms) for the duration of the first agonist burst during a 72 degree elbow flexion movement and also the percentage of agonist EMG bursts until peak velocity | Not Posted | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Number of Agonist Bursts | This is the number of agonist bursts prior to peak velocity. | Not Posted | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Co-contraction During Limb Acceleration | the amount of agonist and antagonist activity present during limb acceleration. | Not Posted | Obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Qant | The integral of the antagonist EMG signal from the onset of the agonist EMG to the end of the movement | Not Posted | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Time to Peak Velocity | Time of the onset of the movement to peak velocity. | Not Posted | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Peak Movement Velocity | This is how fast an individual can perform a 72 degree elbow flexion movement | Not Posted | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Relaxation Time | Time for a subject to passively relax their muscle after performing and isometric contraction to 50% of their MVC | Not Posted | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Rise Time | This is the time is takes for an individual to go for rest to a 50% of a MVC contraction as fast as possible. | Not Posted | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Spatiotemporal Gait Analysis | Spatiotemporal gait analysis using a pressure sensitive walk way allow for measurement of gait velocity, step length, single and double limb support time, cadence, ect. | Not Posted | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Distance Walked in 6 Minutes | This is how far an individual can walk in 6 minutes | Not Posted | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Modified Physical Performance Test | This is an overall measure of physical fuction | Not Posted | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Time on the Timed up and go Test | This is the time it takes an individual to get up from a chair, walk 3 meters, turn around and walk back. | Not Posted | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Berg Balance Scale Score | This is a overall measure of balance | Not Posted | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Functional Reach | The distance one can reach forward without taking a step. | Not Posted | Obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Cognitive Function - Stroop Test | This is a test of cognitive function. This test requires individuals to first say as many colors as they can under three different test conditions. | Not Posted | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Cognitive Function - Brief Test of Attention | This is a cognitive test of an individuals ability to remember number. It is a test of working memory. | Not Posted | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Cognitive Function - Digit Span Forward/Backward | This tests a persons ability to remember that were read to them both forward and then backwards. | Not Posted | obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Parkinson 's Disease Quality of Life | PDQ-39 is a composite measure of quality of life in individuals with Parkinson's Disease. | Not Posted | Obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Epworth Sleepiness Scale | The Epworth Sleepiness Scale is used to determine the level of daytime sleepiness. | Not Posted | Obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | Beck's Depression Inventory | This is a self-report rating inventory that measures characteristic attitudes and symptoms of depression. | Not Posted | Obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | 50 ft Walk Time | Time it takes to walk 50 feet | Not Posted | Obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | 50 Foot Walk Speed | The speed that aerson walks over 50 feet | Not Posted | Obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| Secondary | 5 Time Sit to Stand | The time it takes to stand up and sit down five times | Not Posted | Obtained during initial evaluation & then every 6 six months to end of 2-yr training period |
| 8 |
| 25 |
| 0 |
| 25 |
| EG001 | 2 Modified Fitness Counts | Subjects performed between 60 and 90 minutes of flexibility training two times a week for two years at a local gym. These sessions were supervised by a personal trainer two times a week for the first six months of training and then once a week for the remaining 18 months of training. Exercise inlcuded flexibility training. Participants exercised twice a week for 2 years doing flexibility training. | 6 | 26 | 1 | 26 |
|
| DBS surgery | Nervous system disorders | Non-systematic Assessment |
|
| ALS | Musculoskeletal and connective tissue disorders | Non-systematic Assessment | Developed ALS during the study |
|
| Cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) | Non-systematic Assessment |
|
| Bowel obstruction | Gastrointestinal disorders | Non-systematic Assessment | Hospitalization for bowel obstruction |
|
| Elbow pain | Musculoskeletal and connective tissue disorders | Non-systematic Assessment | Occurred after fall at home and required medical intervention |
|
| Back surgery | Musculoskeletal and connective tissue disorders | Non-systematic Assessment | Back surgery for stenosis |
|
| Bilateral hip replacement | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
| unilateral knee replacement | Musculoskeletal and connective tissue disorders | Non-systematic Assessment | Pt had both knees replaced during separate surgeries |
|
| Knee surgery | Musculoskeletal and connective tissue disorders | Non-systematic Assessment | Knee surgery to remove old debris |
|
| Fall | Musculoskeletal and connective tissue disorders | Non-systematic Assessment | Long term hospitalization after fall at home |
|
| Foot surgery | Musculoskeletal and connective tissue disorders | Non-systematic Assessment |
|
|
Not provided
Not provided
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
| D001519 | Behavior |
| 12 month |
|
| 18 month |
|
| 24 month |
|
| 12 month |
|
| 18 month |
|
| 24 month |
|