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Tiny molecules (hormones) are released from the bowels and other organs to the bloodstream in response to meals in order to orchestrate the metabolism. Oxyntomodulin, GLP-1 and glucagon are all known to regulate parameters such as appetite, food intake and induce weight loss.
Therefore we want to investigate mechanistic relations between the three hormones.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy young males |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| GLP-1 infusion | Other | 1 pmol/kg/min |
| |
| Glucagon infusion |
| Measure | Description | Time Frame |
|---|---|---|
| Gastric emptying | Assessed by the acetaminophen - method | 4 h |
| Satiety | Assessed by VAS | 4 h |
| Hunger | Assessed by an ad'libitum meal | 4 h |
| basal energy expenditure | Assessed by indirect calorimetry | 2 x 30min |
| Measure | Description | Time Frame |
|---|---|---|
| GLP-1 | 4 h | |
| Oxyntomodulin | 4 h | |
| Glucagon | 4 h |
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Inclusion Criteria:
Exclusion Criteria:
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Healthy young males
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| Name | Affiliation | Role |
|---|---|---|
| Jonatan I Bagger, MD | Gentofte University Hospital, University of Copenhagen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gentofte University Hospital | Hellerup | 2900 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26445112 | Derived | Bagger JI, Holst JJ, Hartmann B, Andersen B, Knop FK, Vilsboll T. Effect of Oxyntomodulin, Glucagon, GLP-1, and Combined Glucagon +GLP-1 Infusion on Food Intake, Appetite, and Resting Energy Expenditure. J Clin Endocrinol Metab. 2015 Dec;100(12):4541-52. doi: 10.1210/jc.2015-2335. Epub 2015 Oct 7. |
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blood samples
| Other |
3ng/kg/min |
|
| Oxyntomodulin infusion | Other | 3 pmol/kg/min |
|
| GLP-1 and glucagon infusion | Other | 1 pmol/kg/min 3 ng/kg/min |
|
| Placebo | Other | NaCl 9 g/L infusion |
|
| GIP | 4 h |
| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D052216 | Glucagon-Like Peptide 1 |
| ID | Term |
|---|---|
| D004763 | Glucagon-Like Peptides |
| D052336 | Proglucagon |
| D005768 | Gastrointestinal Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
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