Study to Assess the Effect of Ticagrelor on Coronary Blood Flow in Healthy Male Subjects.

A Randomized, Double-blind, Placebo Controlled, Crossover, Single Centre Phase I Study to Assess the Effect of Ticagrelor on Adenosine-induced Coronary Blood Flow Velocity in Healthy Male Subjects

The purpose of this study is to determine if Ticagrelor increases the Adenosin induced coronary blood flow velocity.

Inclusion Criteria:

• Suitable for ECG recording of CBFV and have no adverse reaction to adenosine challenge
• Have a body mass index between 18 and 30 kg/m2

Exclusion Criteria:

• History of clinically significant disease or disorder.
• Abnormal vital signs