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| Name | Class |
|---|---|
| Technical University of Denmark | OTHER |
| Danish Shellfish Center | OTHER |
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The primary aim of this study is to investigate, whether higher intake of selenium rich food items such as fish and shellfish, is associated with higher selenium blood levels.
The secondary aim is to investigate the uptake of selenium from fish and shellfish and the incorporation of selenium from those foods into proteins in the human body. Furthermore, the impact of the natural variation in the genes that are responsible for the accumulation of selenium in the proteins will be investigated.
Selenium is an essential trace element that is incorporated into proteins in the human body and it hereby plays a major role in several important cellular processes. Previous studies have indicated that the selenium status of the Danish population is below the levels required to optimize the suggested protective effects of selenium towards major diseases including cancer. In Denmark, important natural sources of selenium are fish and shellfish.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Fish and shellfish | Active Comparator |
| |
| Control | No Intervention | Assessment only |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fish and shellfish | Dietary Supplement | Intake of 1000 grams of fish and shellfish per week for six months. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Selenium concentration in whole blood | Measured at baseline | |
| Selenium concentration in whole blood | Measured after 3 months of intervention | |
| Selenium concentration in whole blood | Measured after 6 months of intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Selenoprotein P in plasma | Measured at baseline | |
| Selenoprotein P in plasma | Measured after 3 months of intervention | |
| Selenoprotein P in plasma |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anne Tjonneland, professor, M.D., Ph.D. | Institute of Cancer Epidemiology, Danish Cancer Society | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Cancer Epidemiology, Danish Cancer Society | Copenhagen | 2100 | Denmark |
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| ID | Term |
|---|---|
| D017404 | In Situ Hybridization, Fluorescence |
| D012758 | Shellfish |
| ID | Term |
|---|---|
| D017403 | In Situ Hybridization |
| D013194 | Staining and Labeling |
| D016591 | Histocytological Preparation Techniques |
| D003584 | Cytological Techniques |
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| Measured after 6 months of intervention |
| Genetic polymorphisms in the selenoprotein P gene | Measured at baseline |
| Genetic polymorphisms in the selenoprotein P gene | Measured after 3 months of intervention |
| Genetic polymorphisms in the selenoprotein P gene | Measured after 6 months of intervention |
| Heavy metals in whole blood (lead, cadmium, and mercury) | Measured at baseline |
| Heavy metals in whole blood (lead, cadmium, and mercury) | Measured after 3 months of intervention |
| Heavy metals in whole blood (lead, cadmium, and mercury) | Measured after 6 months of intervention |
| Blood pressure | Measured at baseline |
| Blood pressure | Measured after 3 months of intervention |
| Blood pressure | Measured after 6 months of intervention |
| Anthropometry (weight, height, waist, and hip circumference) | Measured at baseline |
| Anthropometry (weight, height, waist, and hip circumference) | Measured after 3 months of intervention |
| Anthropometry (weight, height, waist, and hip circumference) | Measured after 6 months of intervention |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D006652 | Histological Techniques |
| D008919 | Investigative Techniques |
| D020732 | Cytogenetic Analysis |
| D005821 | Genetic Techniques |
| D009693 | Nucleic Acid Hybridization |
| D017747 | Seafood |
| D008460 | Meat |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |