Selenium in the Prevention of Cancer

Prevention of Cancer by Intervention With Selenium - A Pilot Study in a Danish Population

This is a pilot study proceeding an intended international trial.

Hypothesis: Daily intake of selenium supplementation in the form of selenium-enriched yeast tablets will reduce the risk of cancer in healthy individuals.

Objective: The objective of this pilot study was to assess the viability of a full scale randomised trial.

AMENDMENT TO STUDY OBJECTIVE: Mortality analysis during intervention and follow-up as specified in the sections concerning study design and outcome measures.

Inclusion Criteria:

• WHO performance status 0 or 1
• No active liver- or kidney disease (Serum ALAT (alanine aminotransferase), alkalic phosphatase, bilirubin, creatinin or urea within 2 S.D of laboratory reference range)
• No previous cancer diagnosis
• No known HIV-infection
• Participant must understand oral and written information
• Participant must not use selenium supplementation of above 50 mcg/d
• Participant must give written consent prior to inclusion