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| Name | Class |
|---|---|
| BioGenesis | INDUSTRY |
| HRG | UNKNOWN |
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Hypothesis to be tested is whether follicular addition of Methylprednisolone can efficiently control late follicular progesterone rise during IVF treatment
The aim is to investigate any potential advantages of adding cortisone supplementation from the follicular phase onwards with regard to premature luteinization, oocyte quality, embryo quality and pregnancy outcome.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Follicular Medrol | Active Comparator | In an Antagonist protocol for IVF patients will also receive 4mg tabl. Methylprednisolone twice a day from the day 2 of ovarian stimulation and until the day of the pregnancy test on luteal day-14 post oocyte retrieval |
|
| No medrol group | Placebo Comparator | Patients will receive only Antagonist protocol for IVF as usual |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| In vitro fertilization treatment for infertility | Other | IVF treatment |
|
| Measure | Description | Time Frame |
|---|---|---|
| Progesterone rise above 1.5ng.ml on the day of HCG | Incidence or high progesterone on the day of HCG triggering | up to 14 days of follicular ovarian stimulation |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical pregnancy rate | Success rate in IVF cycles | Follow pregnancy until delivery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Evangelos Papanikolaou, MD | Contact | 0030 2310 424284 | drvagpapanikolaou@yahoo.gr |
| Name | Affiliation | Role |
|---|---|---|
| Basil Tarlatzis, Professor | BioGenesis | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Biogenesis | Recruiting | Thessaloniki | Pylaia | 55536 | Greece |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 8897119 | Background | Bider D, Menashe Y, Goldenberg M, Dulitzky M, Lifshitz A, Dor J. Dexamethasone as an adjuvant therapy for anovulatory, normoandrogenic patients during ovulation induction with exogenous gonadotropins. J Assist Reprod Genet. 1996 Sep;13(8):613-6. doi: 10.1007/BF02069638. |
| Label | URL |
|---|---|
| web page of investigator centre | View source |
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| ID | Term |
|---|---|
| D011247 | Pregnancy |
| D008775 | Methylprednisolone |
| D011374 | Progesterone |
| ID | Term |
|---|---|
| D012098 | Reproduction |
| D055703 | Reproductive Physiological Phenomena |
| D012101 | Reproductive and Urinary Physiological Phenomena |
| D011239 | Prednisolone |
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| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D011282 | Pregnenediones |
| D011283 | Pregnenes |
| D003339 | Corpus Luteum Hormones |
| D042341 | Gonadal Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D045167 | Progesterone Congeners |
| D012739 | Gonadal Steroid Hormones |