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Creatine supplementation may improve strength, muscle mass, bone mass and muscle function in healthy and elderly people. The investigators speculate that creatine supplementation could have therapeutic effects in pediatric rheumatic (i.e., juvenile systemic lupus erythematosus and juvenile dermatomyositis) patients who usually present muscle weakness, muscle wasting and bone mass loss.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| creatine supplementation | Experimental | will receive 5g/d of creatine monohydrate throughout the trial |
|
| placebo | Placebo Comparator | will receive 5g/d of placebo (dextrose) throughout the trial |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| creatine | Dietary Supplement | 5g/d throughout 12 weeks |
| |
| Measure | Description | Time Frame |
|---|---|---|
| muscle strength | after six months |
| Measure | Description | Time Frame |
|---|---|---|
| kidney function parameters | after six months | |
| quality of life | after six months | |
| muscle function |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Bruno Gualano, PhD | Contact | 551130913096 | gualano@usp.br |
| Name | Affiliation | Role |
|---|---|---|
| Bruno Gualano, PhD | University of Sao Paulo | Study Director |
| Eloisa Bonfa, MD, PhD | University of Sao Paulo | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Sao Paulo | Recruiting | São Paulo | São Paulo | 05508-30 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25135060 | Derived | Hayashi AP, Solis MY, Sapienza MT, Otaduy MC, de Sa Pinto AL, Silva CA, Sallum AM, Pereira RM, Gualano B. Efficacy and safety of creatine supplementation in childhood-onset systemic lupus erythematosus: a randomized, double-blind, placebo-controlled, crossover trial. Lupus. 2014 Dec;23(14):1500-11. doi: 10.1177/0961203314546017. Epub 2014 Aug 18. |
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| ID | Term |
|---|---|
| D003882 | Dermatomyositis |
| ID | Term |
|---|---|
| D017285 | Polymyositis |
| D009220 | Myositis |
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
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| ID | Term |
|---|---|
| D003401 | Creatine |
| D005947 | Glucose |
| ID | Term |
|---|---|
| D006146 | Guanidines |
| D000578 | Amidines |
| D009930 | Organic Chemicals |
| D000596 | Amino Acids |
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| placebo (dextrose) |
| Dietary Supplement |
5g/d throughout 12 weeks |
|
| after six months |
| D009468 |
| Neuromuscular Diseases |
| D009422 | Nervous System Diseases |
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D012871 | Skin Diseases |
| D000602 |
| Amino Acids, Peptides, and Proteins |
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D002241 | Carbohydrates |