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Resistance strengthening exercise will increase strength and functional activity greater than ambulation in subjects post-liver transplantation.
Individuals post liver transplantation are significantly muscle wasted due to chronic liver disease. Current Usual care only involves progressive ambulation. Resistance exercise targeted at the lower extremities are anticipated to increase muscle strength in the muscles that extend the hip, extend the knee, and plantar flex the ankle more than seen with the usual care ambulation. The anticipated increases in strength should improve functional performance of activities such as standing from a chair, walking, and climbing stairs. The improvement in strength and functional performance should improve an individuals quality of life.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Resistance Strengthening | Experimental | Body weight antigravity positioning and elastic resistance bands are used to provide resistance for strengthening in supine, sitting, and standing in subjects post liver transplant. |
|
| Usual Care Control | No Intervention | Subjects perform the usual care of progressive ambulation and increased activity post liver transplant |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Resistance Strengthening Exercise Program | Other | Home exercise Program. 3-4 days a week. 30 minutes a session. 12 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Six Minute Walk Test | Baseline | |
| Heel Rise Test | Baseline | |
| 30-Second Chair-Stand Test | Baseline | |
| Bridge Test | Baseline | |
| Six Minute Walk Test | 12 weeks | |
| Heel Rise Test | 12 weeks | |
| 30-Second Chair-Stand Test | 12 weeks | |
| Bridge Test | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Short Form (SF-36) Questionnaire | Baseline | |
| Short Form (SF-36) Questionnaire | 12 weeks | |
| Chronic Liver Disease Questionnaire (CLDQ) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kathryn Roach, PhD, PT | University of Miami | Study Chair |
| David W Mandel, PhD, PT | University of Miami Dept. of Physical Therapy | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Miami Department of Physical Therapy | Coral Gables | Florida | 44146 | United States |
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| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D008107 | Liver Diseases |
| ID | Term |
|---|---|
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D001284 | Atrophy |
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| Baseline |
| Chronic Liver Disease Questionnaire (CLDQ) | 12 weeks |
| D020763 |
| Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D004066 | Digestive System Diseases |