Study of Resistance Strengthening Versus Ambulation Post-Liver Transplant

Comparison of Targeted Lower Extremity Strengthening and Usual Care Progressive Ambulation in Subjects Post Liver Transplant: A Randomized Controlled Trial

Resistance strengthening exercise will increase strength and functional activity greater than ambulation in subjects post-liver transplantation.

Individuals post liver transplantation are significantly muscle wasted due to chronic liver disease. Current Usual care only involves progressive ambulation. Resistance exercise targeted at the lower extremities are anticipated to increase muscle strength in the muscles that extend the hip, extend the knee, and plantar flex the ankle more than seen with the usual care ambulation. The anticipated increases in strength should improve functional performance of activities such as standing from a chair, walking, and climbing stairs. The improvement in strength and functional performance should improve an individuals quality of life.

Inclusion Criteria:

• Undergone Liver Transplantation a minimum of 6 weeks and a maximum of 12 weeks prior to enrollment
• Ambulatory without physical assistance, but permitted to use a cane or walker

Exclusion Criteria:

• Diagnosis of Hepatocellular Carcinoma
• Significant Cardiopulmonary disease
• Neurological / Neuromuscular Disorder including cerebral vascular accident (CVA), Parkinson's Disease, Alzheimer's Disease, Dementia unrelated to Hepatic Encephalopathy, dystonia, multiple sclerosis, and polio.
• Blindness
• Inability to comprehend the English or Spanish Language