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| Name | Class |
|---|---|
| The Danish Diabetes Association | OTHER |
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The investigators wish to investigate wether a more strict diabetic control improves cardiac function, muscle strength, exercise capacity and decreases symptoms.
The investigators hypothesis is that improving the glycemic control in suboptimized diabetics with heart failure will improve cardiac performance, muscle strength, exercise capacity and decrease symptoms.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| optimized diabetic control | Experimental | each participant will be assigned to be optimized in a dedicated diabetic clinic |
|
| control | No Intervention | participants will be assigned to follow what ever control they were in before the study and not to change any antidiabetic treatment during the interventions period. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| all antidiabetic drugs will be appliable | Other | We expect all participants to be set on insulin during the intervention, however all types of insulin and other antidiabetics can be used goal: Hba1c lower than 7,5% |
| Measure | Description | Time Frame |
|---|---|---|
| Left ventricular function | Left ventricular function will be evaluated using echocardiografi measuring: - 2D Ejection fraction (using an ultrasound agent), global and regional tissue velocity, Strain / strain rate - all measures done during rest and dobutamin stress test. | 4 month |
| Measure | Description | Time Frame |
|---|---|---|
| hormonal and metabolic profile | bloodsamples | 4 month |
| 6-minutes hall walk test | using a hall walk protocol | 4 month |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Roni R Nielsen, MD | Dept. of cardiology, University hospital Aarhus Skejby | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dept. of cardiology, Aarhus university hospital Skejby | Aarhus | Central Jutland | 8200 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27158520 | Derived | Nielsen R, Wiggers H, Thomsen HH, Bovin A, Refsgaard J, Abrahamsen J, Moller N, Botker HE, Norrelund H. Effect of tighter glycemic control on cardiac function, exercise capacity, and muscle strength in heart failure patients with type 2 diabetes: a randomized study. BMJ Open Diabetes Res Care. 2016 Apr 29;4(1):e000202. doi: 10.1136/bmjdrc-2016-000202. eCollection 2016. |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| Exercise capacity and peak oxygen consumption | using a treadmill test and continues oxygen consumption measurement | 4 month |
| Muscle strength and mass | muscle strength: hand grip test | 4 month |
| D004700 | Endocrine System Diseases |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |