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| Name | Class |
|---|---|
| Danish Heart Foundation | OTHER |
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The investigators wish to investigate the the short term effect of low circulating free fatty acids in congestive heart failure patients with type 2 diabetes.
Hypothesis: Low levels of circulating free fatty acids decrease myocardial and peripheral muscle lipid content, improves cardiac performance and exercise capacity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High circulating free fatty acids | Experimental | using Heparin af intralipid infusion for 8 hours |
|
| Low circulation free fatty acids | Active Comparator | using hyperinsulinaemic euglycemic clamp for 8 hours |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Metabolic substrate modulation | Other | for high circulation free fatty acids: Heparin (250IE/hour) + intralipid (20%, 62 ml/hour). |
|
| Measure | Description | Time Frame |
|---|---|---|
| Left ventricular function | Left ventricular systolic function (Ejection fraction, tissue velocity, Strain and strain rate). Left ventricular diastolic funtion (E/A ratio, E/e' ratio, IVRT) Cardiac output. All parameters measured at rest and peak exercise and outcome is difference between low and high ciculating free fatty acids. | 1-6 weeks |
| intracellular lipid content | Magnetic Resonans proton spectroscopy (septal myocardial intracellular lipid content) Magnetic Resonans proton spectroscopy (Tibialis anterior muscle intracellular lipid content). Outcome is difference between low and high ciculating free fatty acids. | 1-6 weeks |
| Exercise capacity and oxygen consumption | Using treadmill and continues oxygen consumption measurement. Outcome is difference between low and high ciculating free fatty acids. | 1-6 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Regional left ventricular function | regional speckle tracking during rest and peak exercise. Outcome is difference between low and high ciculating free fatty acids. | 1-6 weeks |
| 6 minutes hall walk test |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Roni R Nielsen, MD | Dept. of cardiolgy, Aarhus University hospital, Skejby. Brendstrupgaardsvej 100, 8200 Aarhus N, Denmark | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dept. of cardiology, Aarhus University hospital Skejby, | Aarhus | Region Midjylland | 8200 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23733915 | Derived | Nielsen R, Norrelund H, Kampmann U, Kim WY, Ringgaard S, Schar M, Moller N, Botker HE, Wiggers H. Failing heart of patients with type 2 diabetes mellitus can adapt to extreme short-term increases in circulating lipids and does not display features of acute myocardial lipotoxicity. Circ Heart Fail. 2013 Jul;6(4):845-52. doi: 10.1161/CIRCHEARTFAILURE.113.000187. Epub 2013 Jun 3. |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| metabolic substrate modulation | Other | low circulating free acids: hyperinsulinaemic euglycemic clamp (0,8 mUkg/min) with venous blood glucose at 4,5-6,5 mM. |
|
distance difference between low and high levels of circulating FFA. Outcome is difference between low and high ciculating free fatty acids.
| 1-6 weeks |
| metabolic and hormonal profile | bloodsamples | 1-6 weeks |
| D009750 |
| Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |