Impact of Intensive Exercise Training on Coronary Collateral Circulation in Patients With Stable CAD

Impact of Intensive Exercise Training Compared to Inactive Controls on Coronary Collateral Circulation and Plaque Composition in Patients With Significant Stable Coronary Artery Disease

Exercise training in patients with coronary artery disease is able to correct several risk factors. Furthermore endothelial function can be improved.

There are some hinds for improved collateral circulation after exercise training, nevertheless there is no study showing significant improvement/ increase in coronary collaterals. This might be due to technique of collateral measurement. Therefore we conduct a study were coronary blod flow before and after 4 weeks of exercise training were measured.

Inclusion Criteria:

• stable CAD
• min.1 coronary artery stenosis >50%
• patient is symptomatic ( CCS 1-3)or has documented myocardial ischemia during stress test
• angina threshold >75 Watt
• informed consent

Exclusion Criteria:

• Age <18 oder >75
• akut coronary syndrome within 2 weeks
• LV-EF < 40 %
• significant valve diseases
• reduced patient compliance
• muscular disorder
• bronchial asthma or COLD stadium III and IV