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Exercise training in patients with coronary artery disease is able to correct several risk factors. Furthermore endothelial function can be improved.
There are some hinds for improved collateral circulation after exercise training, nevertheless there is no study showing significant improvement/ increase in coronary collaterals. This might be due to technique of collateral measurement. Therefore we conduct a study were coronary blod flow before and after 4 weeks of exercise training were measured.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control | No Intervention | standard care of coronary artery diseases incl. recommended home based exercise 3x/week | |
| Exercise training | Active Comparator | exercise training for 4 weeks at 70% of ischemia free individual threshold within a rehabilitation care center |
|
| intensive exercise training | Active Comparator | intensive exercise training incl. interval training |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| exercise training | Behavioral | exercise training min. 4 times a day for at least 30 min |
|
| Measure | Description | Time Frame |
|---|---|---|
| coronary collateral blod flow | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| plaque composition within the coronary artery | plaque composition measured by virtual histology intravascular ultrasound | 4 weeks |
| MACCE | major cardiovascular events (death, myocardial infarction, stroke, TIA, coronary revascularisation, hospitalisation) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sven Möbius-Winkler, MD | Heart Center Leipzig- University Leipzig | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Heart Center Leipzig- University Leipzig | Leipzig | 04289 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26979085 | Derived | Mobius-Winkler S, Uhlemann M, Adams V, Sandri M, Erbs S, Lenk K, Mangner N, Mueller U, Adam J, Grunze M, Brunner S, Hilberg T, Mende M, Linke AP, Schuler G. Coronary Collateral Growth Induced by Physical Exercise: Results of the Impact of Intensive Exercise Training on Coronary Collateral Circulation in Patients With Stable Coronary Artery Disease (EXCITE) Trial. Circulation. 2016 Apr 12;133(15):1438-48; discussion 1448. doi: 10.1161/CIRCULATIONAHA.115.016442. Epub 2016 Mar 15. | |
| 22974129 |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| Intensive exercise training | Behavioral | Intensive exercise training for 4 times / day incl. interval training at 95% individual threshold |
|
| 4 week, 6 months, 12 months |
| atherosclerosis parameter within the laboratory | e.g. wie hs-CRP, HDL, LDL, ges. Cholesterin, Triglyceride, Zytokine, Adipokine, Endocannaboide | 4 weeks, 3, 6, 12 months |
| Derived |
| Uhlemann M, Adams V, Lenk K, Linke A, Erbs S, Adam J, Thiele H, Hilberg T, Gutberlet M, Grunze M, Schuler GC, Mobius-Winkler S. Impact of different exercise training modalities on the coronary collateral circulation and plaque composition in patients with significant coronary artery disease (EXCITE trial): study protocol for a randomized controlled trial. Trials. 2012 Sep 14;13:167. doi: 10.1186/1745-6215-13-167. |