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| Name | Class |
|---|---|
| Norwegian University of Science and Technology | OTHER |
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The purpose of this study is to examine the effect of two different physical exercise protocols on changes in coronary artery plaque composition and development of in-stent restenosis in patients treated with percutaneous coronary intervention with stent implantation. The investigators will compare aerobic interval training and moderate continuous training. Both exercise protocols have a duration of 12 weeks. The investigators hypothesize that aerobic interval training is superior to moderate continuous training regarding effects on the composition of coronary artery plaques and a reduction in the development of in-stent restenosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Aerboic interval training | Experimental |
| |
| Moderate continuous training | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Moderate continuous training | Behavioral | Three training sessions per week in a total of 12 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Artery plaque composition evaluated by intravascular ultrasound and virtual histology | Findings at 12 weeks will be compared to baseline results | After 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Occurrence of in-stent restenosis related to endothelial dysfunction, inflammatory biomarkers and the dimension of the main left coronary artery | Findings at 12 weeks will be compared to baseline results | After 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Rune Wiseth, M.D, PhD | Department of Cardiology, Trondheim University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Cardiology | Trondheim | N-7006 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19853690 | Background | Munk PS, Staal EM, Butt N, Isaksen K, Larsen AI. High-intensity interval training may reduce in-stent restenosis following percutaneous coronary intervention with stent implantation A randomized controlled trial evaluating the relationship to endothelial function and inflammation. Am Heart J. 2009 Nov;158(5):734-41. doi: 10.1016/j.ahj.2009.08.021. | |
| 35226566 |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| Aerobic interval training | Behavioral | Three training sessions per week in a total of 12 weeks |
|
| Taraldsen MD, Wiseth R, Videm V, Bye A, Madssen E. Associations between circulating microRNAs and coronary plaque characteristics: potential impact from physical exercise. Physiol Genomics. 2022 Apr 1;54(4):129-140. doi: 10.1152/physiolgenomics.00071.2021. Epub 2022 Feb 28. |
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |