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Mentalisation based treatment (MBT) for young people with co-morbid depression and emerging personality disorder will be more effective in a day/inpatient setting than treatment as usual.
Systematic literature review on outcomes with young people with depression and emerging personality disorder showed clear evidence that this group of young people are severely hampered and adult outcomes are strongly linked to both adult PD as well as adult psychiatric disturbance and lower levels of adult functioning. (Crawford et al, 2008; Kasen et al, 1999; Kasen et al, 2007; Lewinsohn et al, 1999) This argues very clearly for the need to diagnose young people presenting with co-morbid depression and emerging personality disorder in order to intervene and help these young people's struggles as it will prevent poor prognostic adult outcomes. There were no treatment programs that specifically focussed on the treatment of this co-morbid group in the literature. Several studies focussed on the treatment of depression alone and only one RCT focussed on the treatment of adolescent personality disorder (Chanen et al, 2007). In adult studies mentalization-based treatment programs were found to be effective ( as well as cost effective) in a day hospital setting for adults with personality disorder and depression (Bateman, et al, 2007) This study aims to conduct a control trial to test whether MBT will be more effective than TAU in this group. All cases will be tested on admission, at discharge and followed up at 2 years post discharge.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MBT group | Experimental | mentalization based treatment program |
|
| Treatment as usual group | Active Comparator | treatment as usual group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MBT | Other | The intervention consists of twice weekly individual MBT therapy, group therapy with an MBT focus and weekly MBFT, which is MBT for families. The treatment duration will be 6-8 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| Global assessment of functioning | Measures global functioning | 2 years post discharge |
| Global assessment of functioning | measures level of functioning | within 1 week of admission |
| global assessment of functioning | measures level of functioning | Average of 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| mood and feelings questionnaire | Assesses mood in terms of number of depressive symptoms | 2 years post discharge |
| Mood and feelings questionnaire | Assesses mood in terms of number of depressive symptoms |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| trudie I Rossouw, Dr | Contact | +448446001200 | trudie.rossouw@nelft.nhs.uk |
| Name | Affiliation | Role |
|---|---|---|
| trudie i rossouw, dr | North East London Foundation Trust | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| North East London Foundation Trust | Recruiting | Ilford | Essex | IG3 8XQ | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20148147 | Background | Bateman A, Fonagy P. Mentalization based treatment for borderline personality disorder. World Psychiatry. 2010 Feb;9(1):11-5. doi: 10.1002/j.2051-5545.2010.tb00255.x. | |
| 19833787 | Background | Bateman A, Fonagy P. Randomized controlled trial of outpatient mentalization-based treatment versus structured clinical management for borderline personality disorder. Am J Psychiatry. 2009 Dec;166(12):1355-64. doi: 10.1176/appi.ajp.2009.09040539. Epub 2009 Oct 15. |
| Label | URL |
|---|---|
| host NHS organisation | View source |
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| ID | Term |
|---|---|
| D003863 | Depression |
| D010554 | Personality Disorders |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D013812 | Therapeutics |
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|
| treatment as usual | Other | less intensive and structured psychotherapeutic program |
|
|
| Within 1 week of admission |
| mood and feelings questionnaire | Assesses mood in terms of number of depressive symptoms | At average of 8 weeks |
| 18519822 | Background | Crawford TN, Cohen P, First MB, Skodol AE, Johnson JG, Kasen S. Comorbid Axis I and Axis II disorders in early adolescence: outcomes 20 years later. Arch Gen Psychiatry. 2008 Jun;65(6):641-8. doi: 10.1001/archpsyc.65.6.641. |
| 10518162 | Background | Kasen S, Cohen P, Skodol AE, Johnson JG, Brook JS. Influence of child and adolescent psychiatric disorders on young adult personality disorder. Am J Psychiatry. 1999 Oct;156(10):1529-35. doi: 10.1176/ajp.156.10.1529. |
| 17201867 | Background | Kasen S, Cohen P, Skodol AE, First MB, Johnson JG, Brook JS, Oldham JM. Comorbid personality disorder and treatment use in a community sample of youths: a 20-year follow-up. Acta Psychiatr Scand. 2007 Jan;115(1):56-65. doi: 10.1111/j.1600-0447.2006.00842.x. |
| 9893417 | Background | Lewinsohn PM, Rohde P, Klein DN, Seeley JR. Natural course of adolescent major depressive disorder: I. Continuity into young adulthood. J Am Acad Child Adolesc Psychiatry. 1999 Jan;38(1):56-63. doi: 10.1097/00004583-199901000-00020. |
| 17908019 | Background | Chanen AM, McCutcheon LK, Jovev M, Jackson HJ, McGorry PD. Prevention and early intervention for borderline personality disorder. Med J Aust. 2007 Oct 1;187(S7):S18-21. doi: 10.5694/j.1326-5377.2007.tb01330.x. |