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Evaluate the effectiveness of the use of a 24% sucrose solution for pain management of preterm infants during endotracheal suctioning.
Many infants admitted to neonatal intensive care unit (NICU) undergo repeated invasive procedures. Recent studies have shown that the oral sucrose administration to neonates is safe and effective for pain relief during heel stick and venipuncture.Most data suggest the investigation of the effect of sucrose in other painful procedures such as in ventilated newborns.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| sucrose | Active Comparator | 0,5 ml/kg of sucrose administered 2 minutes prior the procedure |
|
| sterile water | Placebo Comparator | 0,5 ml/kg of sterile water administered 2 minutes prior the procedure |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| sucrose | Drug | oral sucrose solution, 24%, 0,5 ml/kg, 2 minutes before start the suctioning sterile water, 0,5 ml/kg, 2 minutes before start the suctioning |
|
| Measure | Description | Time Frame |
|---|---|---|
| clinical pain score | The tool that will be used is PIPP = Premature Infant Pain Profile. This avaliation begins prior to suctioning until 30 seconds after suctioning. Each infant will be avaliated 2 times (with sucrose and with placebo). The 2 avaliations in the same day. | within the first twelve hours after clinical stabilization, the PIPP will be done. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Rita A Almeida, postgraduate | Universidade Federal de Pernambuco | Principal Investigator |
| Sônia B Coutinho, Dr. | Universidade Federal de Pernambuco | Study Director |
| Pedro I Lira, Dr. | Universidade Federal de Pernambuco | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Agamenon Magalhães, Hospital Barão de Lucena | Recife | Pernambuco | Brazil |
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| ID | Term |
|---|---|
| D010146 | Pain |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D013395 | Sucrose |
| D000073893 | Sugars |
| ID | Term |
|---|---|
| D004187 | Disaccharides |
| D009844 | Oligosaccharides |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
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