Study of Administration Of Antithrombin in Patients With Low Plasmatic Levels of Antithrombin After Cardiac Surgery

Effects of the Administration Of Antithrombin on the Coagulation Status and on the Inflammatory Response in Patients With Low Plasmatic Levels of Antithrombin After Cardiac Surgery

General and specific objectives of the search: evaluate the effects of the administration of Antithrombin III (ATIII) on the activation of the coagulation system and of the fibrinolysis, platelet function, inflammatory response and markers of organ damage in patients undergoing cardiac surgery by cardiopulmonary bypass (CPB) with low plasma levels of post-operative Antithrombin (AT).

Inclusion Criteria:

• All patients were candidates for cardiac surgery intervention in extracorporeal circulation

Exclusion Criteria:

• positive history for allergic reactions to AT III
• cardiac surgery "Off-Pump"
• administration of AT during surgery or within 48 h
• treatment with drugs and non-steroidal steroids within 48 h prior
• disorders of coagulation
• platelets <30,000
• pre-existing IRC in dialysis treatment
• severe liver failure
• enlistment in another trial in the last 30 days
• hypothermia
• emergency
• reopening
• length of CEC> 180 minutes
• subjects incapable of giving legal consent