Single Dose Study Of PF-04171327 And Prednisone On Carbohydrate Metabolism

An Open Label Study Evaluating The Effect Of Single Doses Of PF-04171327 And Prednisone On Carbohydrate Metabolism Utilizing An Oral Glucose Tolerance Test In Healthy Adult Subjects

This study will investigate the effect of a single dose of PF-04171327 or prednisone on calculated measures of glucose tolerance and insulin resistance by using a modified oral glucose tolerance test

Inclusion Criteria:

• BMI 17.5 to 30.5 kg/m2 and total body weight >50 kg

Exclusion Criteria:

• Fasting glucose above the limits of the reference range for healthy individuals
• "No treatment" Oral Glucose Tolerance Test (OGTT) indicative of impaired fasting glucose or impaired glucose tolerance
• Severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation