The Dose Response of Prednisone on Biochemical and Clinical Makers in Adult Healthy Volunteers

A Randomized, Single-blind, Placebo-controlled, Crossover Studyto Assess The Dose Response Of Prednisone On Biochemical Andclinical Markers Of Efficacy And Safety In Adult Healthyvolunteers

The purpose of this study is to further access the utility of biochemical and clinical biomarkers for glucocorticoid-mediated anti-inflammatory effects and safety endpoints against which dissociated agonists of the glucocorticoid receptor (DAGR) will be evaluated in adult healthy volunteers.

Inclusion Criteria:

• Healthy male or females willing to be confined and comply with scheduled visits
• Women are to be surgically sterile.

Exclusion Criteria:

• History of febrile illness within 5 days prior to the first dose
• Positive urine drug screen
• Treatment with an investigational product within 30 days prior to the first dose of study medication