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| Name | Class |
|---|---|
| U.S. Army Medical Research and Development Command | FED |
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The goal of this multicenter study is to develop a standardized scoring system for inhalation injury that can be used both to quantify and predict injury severity inhalation injury in adults over 18 years of age. A model will be developed based on clinical, radiographic, bronchoscopic, and biochemical parameters that will predict the severity of inhalation injury with greater than 80% predictive accuracy
The goal of this multicenter study is to develop a standardized scoring system for inhalation injury that can be used both to quantify and predict injury severity inhalation injury in adults over 18 years of age. A model will be developed based on clinical, radiographic, bronchoscopic, and biochemical parameters that will predict the severity of inhalation injury with greater than 80% predictive accuracy
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intubated within 24hrs of admission | All patients that are admitted to a participating burn center and intubated within 24 hours |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Standard of Care | Other | bronchoscopy with collection of bronchioalveolar lavage specimen, blood samples, High-Resolution spiral computed tomography(CT) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Development of a diagnostic model to predict the severity of inhalation injury | The development of a diagnostic model to predict the severity of inhalation injury based on demographics, characteristics of injury, bronchoscopy, CT scan, and inflammatory markers. | within 48 hours of admission |
| Measure | Description | Time Frame |
|---|---|---|
| Impact of inhalation injury | Assessment of the impact of inhalation injury on the incidence of pneumonia, acute respiratory distress syndrome (ARDS), and acute lung injury (ALI). | at discharge |
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Inclusion Criteria:
Injury consistent with inhalation of smoke or products of combustion
Requires intubation within 24 hours of injury
Meets one of the following 4 criteria
Exclusion Criteria:
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Study population includes all patients admitted to a participating burn center and who are intubated withing 24 hours of injury
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| Name | Affiliation | Role |
|---|---|---|
| Kevin N. Foster, MD | The Arizona burn Center, Maricopa Integrated Health Systems | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Arizona Burn Center, Maricopa Integrated Health Systems | Phoenix | Arizona | 85008 | United States | ||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37352120 | Derived | Ronkar NC, Galet C, Richey K, Foster K, Wibbenmeyer L. Predictors and Impact of Pneumonia on Adverse Outcomes in Inhalation Injury Patients. J Burn Care Res. 2023 Nov 2;44(6):1289-1297. doi: 10.1093/jbcr/irad099. |
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| ID | Term |
|---|---|
| D015208 | Smoke Inhalation Injury |
| ID | Term |
|---|---|
| D002059 | Burns, Inhalation |
| D002056 | Burns |
| D014947 | Wounds and Injuries |
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| ID | Term |
|---|---|
| D059039 | Standard of Care |
| ID | Term |
|---|---|
| D019984 | Quality Indicators, Health Care |
| D011787 | Quality of Health Care |
| D006298 | Health Services Administration |
| D017530 | Health Care Quality, Access, and Evaluation |
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bronchioalveolar lavage specimens, blood samples
| Arkensas Children's Hopital |
| Little Rock |
| Arkansas |
| 72202 |
| United States |
| University of California Davis Medical Center | Sacramento | California | 95817 | United States |
| Loyola University | Maywood | Illinois | 60153 | United States |
| Indiana University | Indianapolis | Indiana | 46202 | United States |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | United States |
| The Metro Health System | Cleveland | Ohio | 44109 | United States |
| University of Tennessee Health Science Center | Memphis | Tennessee | 38103 | United States |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | United States |