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| Name | Class |
|---|---|
| Illinois Institute of Technology | OTHER |
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Determine whether eating beans with a high fat meal will reduce the inflammatory response in people with the metabolic syndrome and increase feelings of satiety.
Determine whether eating beans with a high fat meal will reduce the inflammatory response in people with the metabolic syndrome; thereby possibly postponing the diagnosis of diabetes or other chronic inflammatory diseases. These researchers are also interested in how consuming beans can affect the length of time a person stays full after a meal.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bean Soup | Experimental | Experimental soup with a high fiber content and ORAC value. The ORAC value is the Oxygen Radical Absorbance Capacity (ORAC) score which is a measure of the antioxidant levels of food and is expressed as Trolox Equivalents. The antioxidants in the soup are derived from beans. |
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| Couscous plus Fiber | Active Comparator | Soup with added fiber; has a low ORAC value. Subject serving is isocaloric to the experimental Bean soup. |
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| Couscous plus Grape Seed Extract | Active Comparator | Control for ORAC value of the Bean soup; for examining the effect of fiber in the bean soup. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Couscous plus fiber | Other | Soup with added fiber to equal Bean soup. Subjects' serving size is isocaloric to the experimental Bean soup. |
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| Measure | Description | Time Frame |
|---|---|---|
| Inflammation | Measuring inflammatory markers after consumption of a high fat meal in conjunction with one of three soups. The three soups are: a bean soup high in fiber and antioxidants, a couscous soup high in fiber, and a couscous soup high in antioxidants. | 6 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Satiety | Measure subjects' perception of fullness during the 6 hour post-prandial testing period. Subjects will keep food records on the study day and day following to look for any longer effects on satiety as measured by food intake. | 48 hours |
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Inclusion Criteria:
Men and Women 21 years old and older with metabolic syndrome
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Chulani T Kappagoda, M.D., Ph.D. | University of California, Davis | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ragle Human Nutrition Research Center | Davis | California | 95616 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28735851 | Derived | Reverri EJ, Randolph JM, Kappagoda CT, Park E, Edirisinghe I, Burton-Freeman BM. Assessing beans as a source of intrinsic fiber on satiety in men and women with metabolic syndrome. Appetite. 2017 Nov 1;118:75-81. doi: 10.1016/j.appet.2017.07.013. Epub 2017 Jul 20. |
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| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| ID | Term |
|---|---|
| D004043 | Dietary Fiber |
| D000975 | Antioxidants |
| D056604 | Grape Seed Extract |
| ID | Term |
|---|---|
| D004040 | Dietary Carbohydrates |
| D002241 | Carbohydrates |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
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| Grape seed extract | Dietary Supplement | 300 milligrams of grape seed extract in capsule form will be consumed with the low ORAC value soup. |
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| Bean Soup | Other | Experimental soup with a high fiber content and ORAC value. The ORAC value is the Oxygen Radical Absorbance Capacity (ORAC) score which is a measure of the antioxidant levels of food and is expressed as Trolox Equivalents. The antioxidants in the soup are derived from beans. |
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| D009750 |
| Nutritional and Metabolic Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010829 |
| Physiological Phenomena |
| D019602 | Food and Beverages |
| D001685 | Biological Factors |
| D045504 | Molecular Mechanisms of Pharmacological Action |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D020011 | Protective Agents |
| D045505 | Physiological Effects of Drugs |
| D020313 | Specialty Uses of Chemicals |
| D010936 | Plant Extracts |
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
| D004364 | Pharmaceutical Preparations |